ArticleScientific reports2017
A high-glucose diet affects Achilles tendon healing in rats.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Achilles tenocytes from diabetic and non diabetic donors exposed to hyperglycemia respond differentially to inflammatory stimuli and stretch.Journal of anatomy · 2026Article
- Regulating inflammation microenvironment and tenogenic differentiation as sequential therapy promotes tendon healing in diabetic rats.Journal of orthopaedic translation · 2025Article
- Low-temperature plasma improves the healing process of Achilles tendinopathy in a rat model.Frontiers in bioengineering and biotechnology · 2025Article
- Advanced glycation end products impair the repair of injured tendon: a study in rats.BMC musculoskeletal disorders · 2024Article
- Effect of Aging on Tendon Biology, Biomechanics and Implications for Treatment Approaches.International journal of molecular sciences · 2023Review
- iPSC-derived tenocytes seeded on microgrooved 3D printed scaffolds for Achilles tendon regeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Animal model for tendinopathy.Journal of orthopaedic translation · 2023Review
- Nanofiber matrix formulations for the delivery of Exendin-4 for tendon regeneration:Bioactive materials · 2023Article
- Predicting the formation of different tissue types during Achilles tendon healing using mechanoregulated and oxygen-regulated frameworks.Biomechanics and modeling in mechanobiology · 2023Article
- Untargeted metabolomics analysis identifies creatine, myo-inositol, and lipid pathway modulation in a murine model of tendinopathy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Patellar Tendon Shear Wave Velocity Is Higher and has Different Regional Patterns in Elite Competitive Alpine Skiers than in Healthy Controls.Frontiers in bioengineering and biotechnology · 2022Article
- CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4.International journal of molecular sciences · 2021Article
- Metabolic Regulation of Tendon Inflammation and Healing Following Injury.Current rheumatology reports · 2021Review
- Effects of Long-Term Physical Activity and Diet on Skin Glycation and Achilles Tendon Structure.Nutrients · 2019Article
- Local treatment with ascorbic acid accelerates recovery of post-sutured Achilles tendon in male Wistar rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Control of glucose metabolism is important in tenogenic differentiation of progenitors derived from human injured tendons.PloS one · 2019Article
- Obesity/Type II Diabetes Promotes Function-limiting Changes in Murine Tendons that are not reversed by Restoring Normal Metabolic Function.Scientific reports · 2018Article
- Metabolic shift from glycogen to trehalose promotes lifespan and healthspan inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Tenomodulin is essential for prevention of adipocyte accumulation and fibrovascular scar formation during early tendon healing.Cell death & disease · 2017Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic and acute tendinopathies are difficult to treat and tendon healing is generally a very slow and incomplete process and our general understanding of tendon biology and regeneration lags behind that of muscle or bone. Although still largely unexplored, several studies suggest a positive effect of nutritional interventions on tendon health and repair. With this study, we aim to reveal effects of a high-glucose diet on tendon neoformation in a non-diabetic rat model of Achilles tenotomy. After surgery animals received either a high-glucose diet or a control diet for 2 and 4 weeks, respectively. Compared to the control group, tendon repair tissue thickness and stiffness were increased in the high-glucose group after 2 weeks and gait pattern was altered after 1 and 2 weeks. Cell proliferation was up to 3-fold higher and the expression of the chondrogenic marker genes Sox9, Col2a1, Acan and Comp was significantly increased 2 and 4 weeks post-surgery. Further, a moderate increase in cartilage-like areas within the repair tissue was evident after 4 weeks of a high-glucose diet regimen. In summary, we propose that a high-glucose diet significantly affects tendon healing after injury in non-diabetic rats, potentially driving chondrogenic degeneration.
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