Evidence map›Paper›PMID 28396559›Full record

ArticleMolecular and cellular biology2017

An mRNA Capping Enzyme Targets FACT to the Active Gene To Enhance the Engagement of RNA Polymerase II into Transcriptional Elongation.

Rwik Sen, Amala Kaja, Jannatul Ferdoush, Shweta Lahudkar, Priyanka Barman, Sukesh R Bhaumik

Open access · bronzeAbstract read
In one paragraph

Article in Molecular and cellular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Facilitates Chromatin Transcription in Breast and Other Cancers.Advances in experimental medicine and biology · 2024
    Review
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Rwik SenDepartment of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, Illinois, USA.
Amala KajaDepartment of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, Illinois, USA.
Jannatul FerdoushDepartment of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, Illinois, USA.
Shweta LahudkarDepartment of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, Illinois, USA.
Priyanka BarmanDepartment of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, Illinois, USA.
Sukesh R BhaumikDepartment of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, Illinois, USA sbhaumik@siumed.edu.
University of Colorado Denver · USSouthern Illinois University School of Medicine · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Ubiquitin-proteasome system regulation of a transcriptional co-activator, SAGA, and associated functionsR15GM088798 · NIGMS · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI BHAUMIK, SUKESH R. · 2009 to 2018
$997k
NIGMS NIH HHS R15 GM088798
6 · The paper itself

Abstract

We have recently demonstrated that an mRNA capping enzyme, Cet1, impairs promoter-proximal accumulation/pausing of RNA polymerase II (Pol II) independently of its capping activity in

Indexed as

Transcription Elongation, GeneticAcid Anhydride HydrolasesAlcohol DehydrogenaseBinding SitesChromatinDNA-Binding ProteinsHigh Mobility Group ProteinsPromoter Regions, GeneticRNA, MessengerRNA Polymerase IISaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscriptional Elongation FactorsAcid Anhydride HydrolasesADH1 protein, S cerevisiaeAlcohol DehydrogenaseChromatinDNA-Binding ProteinsFACT protein, S cerevisiaeHigh Mobility Group ProteinsRNA, MessengerRNA Polymerase IIRNA triphosphataseSaccharomyces cerevisiae ProteinsTranscriptional Elongation FactorsCet1FACTmRNA cappingRNA polymerase IItranscription

Identifiers

PMID28396559
PMCPMC5472824
OpenAlexW2607083729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.