ArticleHypertension (Dallas, Tex. : 1979)2017
Transcriptome Analysis of Human Reninomas as an Approach to Understanding Juxtaglomerular Cell Biology.
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Article in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Spatial transcriptional mapping reveals the molecular characteristics of juxtaglomerular cell tumors.Frontiers in oncology · 2026Article
- Small Interfering RNA Therapy for the Management and Prevention of Hypertension.Current hypertension reports · 2025Review
- Targetable NOTCH1 rearrangements in reninoma.Nature communications · 2023Article
- Flexible and multifaceted: the plasticity of renin-expressing cells.Pflugers Archiv : European journal of physiology · 2022Review
- Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell-Specific Changes in the Kidney and Increases Blood Pressure.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Juxtaglomerular Cell Tumor: Reviewing a Cryptic Cause of Surgically Correctable Hypertension.Current urology · 2019Review
- Juxtaglomerular Cell Phenotypic Plasticity.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2017Review
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Authors and funding
14 authors at 1 institution in 1 country.
Alexandre G MartiniFrom the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands (A.G.M., E.C.H.F., A.H.v.d.M., A.H.J.D.); Laboratory of Molecular Biochemistry of Hypertension (L.K.X., M.-J.L., C.M., T.L.R.) and Laboratory of Bioinformatics and Computational Genomics (A.B.-C., B.H.-K.), Institut de Recherches Cliniques de Montréal (IRCM), Quebec, Canada; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Quebec, Canada (L.K.X., T.L.R.); Department of Biochemistry (B.H.-K., T.L.R.) and Department of Medicine (T.L.R.), Université de Montréal, Quebec, Canada; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY (K.W.G.); Hôpital Européen Georges Pompidou, Centre d'Investigations Cliniques 1418, Paris, France (M.A.); Collège de France, Center for Interdisciplinary Research in Biology (CIRB), Paris, France (P.C., G.N.); and INSERM, U1050, Paris, France (G.N.).
Lucie K XaFrom the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands (A.G.M., E.C.H.F., A.H.v.d.M., A.H.J.D.); Laboratory of Molecular Biochemistry of Hypertension (L.K.X., M.-J.L., C.M., T.L.R.) and Laboratory of Bioinformatics and Computational Genomics (A.B.-C., B.H.-K.), Institut de Recherches Cliniques de Montréal (IRCM), Quebec, Canada; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Quebec, Canada (L.K.X., T.L.R.); Department of Biochemistry (B.H.-K., T.L.R.) and Department of Medicine (T.L.R.), Université de Montréal, Quebec, Canada; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY (K.W.G.); Hôpital Européen Georges Pompidou, Centre d'Investigations Cliniques 1418, Paris, France (M.A.); Collège de France, Center for Interdisciplinary Research in Biology (CIRB), Paris, France (P.C., G.N.); and INSERM, U1050, Paris, France (G.N.).
Marie-Josée LacombeFrom the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands (A.G.M., E.C.H.F., A.H.v.d.M., A.H.J.D.); Laboratory of Molecular Biochemistry of Hypertension (L.K.X., M.-J.L., C.M., T.L.R.) and Laboratory of Bioinformatics and Computational Genomics (A.B.-C., B.H.-K.), Institut de Recherches Cliniques de Montréal (IRCM), Quebec, Canada; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Quebec, Canada (L.K.X., T.L.R.); Department of Biochemistry (B.H.-K., T.L.R.) and Department of Medicine (T.L.R.), Université de Montréal, Quebec, Canada; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY (K.W.G.); Hôpital Européen Georges Pompidou, Centre d'Investigations Cliniques 1418, Paris, France (M.A.); Collège de France, Center for Interdisciplinary Research in Biology (CIRB), Paris, France (P.C., G.N.); and INSERM, U1050, Paris, France (G.N.).
Alexis Blanchet-CohenFrom the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands (A.G.M., E.C.H.F., A.H.v.d.M., A.H.J.D.); Laboratory of Molecular Biochemistry of Hypertension (L.K.X., M.-J.L., C.M., T.L.R.) and Laboratory of Bioinformatics and Computational Genomics (A.B.-C., B.H.-K.), Institut de Recherches Cliniques de Montréal (IRCM), Quebec, Canada; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Quebec, Canada (L.K.X., T.L.R.); Department of Biochemistry (B.H.-K., T.L.R.) and Department of Medicine (T.L.R.), Université de Montréal, Quebec, Canada; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY (K.W.G.); Hôpital Européen Georges Pompidou, Centre d'Investigations Cliniques 1418, Paris, France (M.A.); Collège de France, Center for Interdisciplinary Research in Biology (CIRB), Paris, France (P.C., G.N.); and INSERM, U1050, Paris, France (G.N.).
Chantal MercureFrom the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands (A.G.M., E.C.H.F., A.H.v.d.M., A.H.J.D.); Laboratory of Molecular Biochemistry of Hypertension (L.K.X., M.-J.L., C.M., T.L.R.) and Laboratory of Bioinformatics and Computational Genomics (A.B.-C., B.H.-K.), Institut de Recherches Cliniques de Montréal (IRCM), Quebec, Canada; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Quebec, Canada (L.K.X., T.L.R.); Department of Biochemistry (B.H.-K., T.L.R.) and Department of Medicine (T.L.R.), Université de Montréal, Quebec, Canada; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY (K.W.G.); Hôpital Européen Georges Pompidou, Centre d'Investigations Cliniques 1418, Paris, France (M.A.); Collège de France, Center for Interdisciplinary Research in Biology (CIRB), Paris, France (P.C., G.N.); and INSERM, U1050, Paris, France (G.N.).
Benjamin Haibe-KainsFrom the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands (A.G.M., E.C.H.F., A.H.v.d.M., A.H.J.D.); Laboratory of Molecular Biochemistry of Hypertension (L.K.X., M.-J.L., C.M., T.L.R.) and Laboratory of Bioinformatics and Computational Genomics (A.B.-C., B.H.-K.), Institut de Recherches Cliniques de Montréal (IRCM), Quebec, Canada; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Quebec, Canada (L.K.X., T.L.R.); Department of Biochemistry (B.H.-K., T.L.R.) and Department of Medicine (T.L.R.), Université de Montréal, Quebec, Canada; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY (K.W.G.); Hôpital Européen Georges Pompidou, Centre d'Investigations Cliniques 1418, Paris, France (M.A.); Collège de France, Center for Interdisciplinary Research in Biology (CIRB), Paris, France (P.C., G.N.); and INSERM, U1050, Paris, France (G.N.).
Edith C H FriesemaFrom the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands (A.G.M., E.C.H.F., A.H.v.d.M., A.H.J.D.); Laboratory of Molecular Biochemistry of Hypertension (L.K.X., M.-J.L., C.M., T.L.R.) and Laboratory of Bioinformatics and Computational Genomics (A.B.-C., B.H.-K.), Institut de Recherches Cliniques de Montréal (IRCM), Quebec, Canada; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Quebec, Canada (L.K.X., T.L.R.); Department of Biochemistry (B.H.-K., T.L.R.) and Department of Medicine (T.L.R.), Université de Montréal, Quebec, Canada; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY (K.W.G.); Hôpital Européen Georges Pompidou, Centre d'Investigations Cliniques 1418, Paris, France (M.A.); Collège de France, Center for Interdisciplinary Research in Biology (CIRB), Paris, France (P.C., G.N.); and INSERM, U1050, Paris, France (G.N.).
Anton H van den MeirackerFrom the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands (A.G.M., E.C.H.F., A.H.v.d.M., A.H.J.D.); Laboratory of Molecular Biochemistry of Hypertension (L.K.X., M.-J.L., C.M., T.L.R.) and Laboratory of Bioinformatics and Computational Genomics (A.B.-C., B.H.-K.), Institut de Recherches Cliniques de Montréal (IRCM), Quebec, Canada; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Quebec, Canada (L.K.X., T.L.R.); Department of Biochemistry (B.H.-K., T.L.R.) and Department of Medicine (T.L.R.), Université de Montréal, Quebec, Canada; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY (K.W.G.); Hôpital Européen Georges Pompidou, Centre d'Investigations Cliniques 1418, Paris, France (M.A.); Collège de France, Center for Interdisciplinary Research in Biology (CIRB), Paris, France (P.C., G.N.); and INSERM, U1050, Paris, France (G.N.).
Kenneth W GrossFrom the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands (A.G.M., E.C.H.F., A.H.v.d.M., A.H.J.D.); Laboratory of Molecular Biochemistry of Hypertension (L.K.X., M.-J.L., C.M., T.L.R.) and Laboratory of Bioinformatics and Computational Genomics (A.B.-C., B.H.-K.), Institut de Recherches Cliniques de Montréal (IRCM), Quebec, Canada; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Quebec, Canada (L.K.X., T.L.R.); Department of Biochemistry (B.H.-K., T.L.R.) and Department of Medicine (T.L.R.), Université de Montréal, Quebec, Canada; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY (K.W.G.); Hôpital Européen Georges Pompidou, Centre d'Investigations Cliniques 1418, Paris, France (M.A.); Collège de France, Center for Interdisciplinary Research in Biology (CIRB), Paris, France (P.C., G.N.); and INSERM, U1050, Paris, France (G.N.).
Michel AziziFrom the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands (A.G.M., E.C.H.F., A.H.v.d.M., A.H.J.D.); Laboratory of Molecular Biochemistry of Hypertension (L.K.X., M.-J.L., C.M., T.L.R.) and Laboratory of Bioinformatics and Computational Genomics (A.B.-C., B.H.-K.), Institut de Recherches Cliniques de Montréal (IRCM), Quebec, Canada; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Quebec, Canada (L.K.X., T.L.R.); Department of Biochemistry (B.H.-K., T.L.R.) and Department of Medicine (T.L.R.), Université de Montréal, Quebec, Canada; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY (K.W.G.); Hôpital Européen Georges Pompidou, Centre d'Investigations Cliniques 1418, Paris, France (M.A.); Collège de France, Center for Interdisciplinary Research in Biology (CIRB), Paris, France (P.C., G.N.); and INSERM, U1050, Paris, France (G.N.).
Pierre CorvolFrom the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands (A.G.M., E.C.H.F., A.H.v.d.M., A.H.J.D.); Laboratory of Molecular Biochemistry of Hypertension (L.K.X., M.-J.L., C.M., T.L.R.) and Laboratory of Bioinformatics and Computational Genomics (A.B.-C., B.H.-K.), Institut de Recherches Cliniques de Montréal (IRCM), Quebec, Canada; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Quebec, Canada (L.K.X., T.L.R.); Department of Biochemistry (B.H.-K., T.L.R.) and Department of Medicine (T.L.R.), Université de Montréal, Quebec, Canada; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY (K.W.G.); Hôpital Européen Georges Pompidou, Centre d'Investigations Cliniques 1418, Paris, France (M.A.); Collège de France, Center for Interdisciplinary Research in Biology (CIRB), Paris, France (P.C., G.N.); and INSERM, U1050, Paris, France (G.N.).
Geneviève NguyenFrom the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands (A.G.M., E.C.H.F., A.H.v.d.M., A.H.J.D.); Laboratory of Molecular Biochemistry of Hypertension (L.K.X., M.-J.L., C.M., T.L.R.) and Laboratory of Bioinformatics and Computational Genomics (A.B.-C., B.H.-K.), Institut de Recherches Cliniques de Montréal (IRCM), Quebec, Canada; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Quebec, Canada (L.K.X., T.L.R.); Department of Biochemistry (B.H.-K., T.L.R.) and Department of Medicine (T.L.R.), Université de Montréal, Quebec, Canada; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY (K.W.G.); Hôpital Européen Georges Pompidou, Centre d'Investigations Cliniques 1418, Paris, France (M.A.); Collège de France, Center for Interdisciplinary Research in Biology (CIRB), Paris, France (P.C., G.N.); and INSERM, U1050, Paris, France (G.N.).
Timothy L ReudelhuberFrom the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands (A.G.M., E.C.H.F., A.H.v.d.M., A.H.J.D.); Laboratory of Molecular Biochemistry of Hypertension (L.K.X., M.-J.L., C.M., T.L.R.) and Laboratory of Bioinformatics and Computational Genomics (A.B.-C., B.H.-K.), Institut de Recherches Cliniques de Montréal (IRCM), Quebec, Canada; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Quebec, Canada (L.K.X., T.L.R.); Department of Biochemistry (B.H.-K., T.L.R.) and Department of Medicine (T.L.R.), Université de Montréal, Quebec, Canada; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY (K.W.G.); Hôpital Européen Georges Pompidou, Centre d'Investigations Cliniques 1418, Paris, France (M.A.); Collège de France, Center for Interdisciplinary Research in Biology (CIRB), Paris, France (P.C., G.N.); and INSERM, U1050, Paris, France (G.N.).
A H Jan DanserFrom the Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands (A.G.M., E.C.H.F., A.H.v.d.M., A.H.J.D.); Laboratory of Molecular Biochemistry of Hypertension (L.K.X., M.-J.L., C.M., T.L.R.) and Laboratory of Bioinformatics and Computational Genomics (A.B.-C., B.H.-K.), Institut de Recherches Cliniques de Montréal (IRCM), Quebec, Canada; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Quebec, Canada (L.K.X., T.L.R.); Department of Biochemistry (B.H.-K., T.L.R.) and Department of Medicine (T.L.R.), Université de Montréal, Quebec, Canada; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY (K.W.G.); Hôpital Européen Georges Pompidou, Centre d'Investigations Cliniques 1418, Paris, France (M.A.); Collège de France, Center for Interdisciplinary Research in Biology (CIRB), Paris, France (P.C., G.N.); and INSERM, U1050, Paris, France (G.N.). a.danser@erasmusmc.nl.
Roswell Park Comprehensive Cancer Center · US
Funding
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6MRENIN-EXPRESSING CELL LINES FOR HYPERTENSION RESEARCHR01HL048459 · NHLBI · ROSWELL PARK CANCER INSTITUTE CORP · PI GROSS, KENNETH W · 1992 to 2010
$4.2MNCI NIH HHS P30 CA016056NHLBI NIH HHS R01 HL048459
Abstract
Renin, a key component in the regulation of blood pressure in mammals, is produced by the rare and highly specialized juxtaglomerular cells of the kidney. Chronic stimulation of renin release results in a recruitment of new juxtaglomerular cells by the apparent conversion of adjacent smooth muscle cells along the afferent arterioles. Because juxtaglomerular cells rapidly dedifferentiate when removed from the kidney, their developmental origin and the mechanism that explains their phenotypic plasticity remain unclear. To overcome this limitation, we have performed RNA expression analysis on 4 human renin-producing tumors. The most highly expressed genes that were common between the reninomas were subsequently used for in situ hybridization in kidneys of 5-day-old mice, adult mice, and adult mice treated with captopril. From the top 100 genes, 10 encoding for ligands were selected for further analysis. Medium of human embryonic kidney 293 cells transfected with the mouse cDNA encoding these ligands was applied to (pro)renin-synthesizing As4.1 cells. Among the ligands, only platelet-derived growth factor B reduced the medium and cellular (pro)renin levels, as well as As4.1 renin gene expression. In addition, platelet-derived growth factor B-exposed As4.1 cells displayed a more elongated and aligned shape with no alteration in viability. This was accompanied by a downregulated expression of α-smooth muscle actin and an upregulated expression of interleukin-6, suggesting a phenotypic shift from myoendocrine to inflammatory. Our results add 36 new genes to the list that characterize renin-producing cells and reveal a novel role for platelet-derived growth factor B as a regulator of renin-synthesizing cells.
Indexed as
Gene Expression ProfilingAnalysis of VarianceAnimalsCells, CulturedDisease Models, AnimalGene ExpressionHumansIn Situ HybridizationJuxtaglomerular ApparatusKidney DiseasesMiceMice, Inbred C57BLPlatelet-Derived Growth FactorRandom AllocationReninSignal TransductionPlatelet-Derived Growth FactorReningene expressionhypertensionplatelet-derived growth factorrenin-producing tumortranscriptome
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