ArticleGenome research2017
Cytosine modifications modulate the chromatin architecture of transcriptional enhancers.
Article in Genome research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- TDG orchestrates ATF4-dependent gene transcription during retinoic acid-induced cell fate acquisition.Nucleic acids research · 2026Article
- tet2 and tet3 regulate cell fate specification and differentiation events during retinal development.Scientific reports · 2025Article
- Super-enhancer DNA methylation in cancer: the mechanism of action and therapeutic directions.Frontiers in oncology · 2025Review
- tet2 and tet3 regulate cell fate specification and differentiation events during retinal development.bioRxiv : the preprint server for biology · 2024Article
- Rockfish: A transformer-based model for accurate 5-methylcytosine prediction from nanopore sequencing.Nature communications · 2024Article
- Epigenetic remodelling of enhancers in response to estrogen deprivation and re-stimulation.Nucleic acids research · 2021Article
- Hydroxycarbamide effects on DNA methylation and gene expression in myeloproliferative neoplasms.Genome research · 2021Article
- 5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer's disease.Cell reports · 2021Article
- B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers.Nature communications · 2021Article
- TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment.Cellular and molecular life sciences : CMLS · 2021Article
- DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma.Clinical epigenetics · 2020Article
- Genome-wide characterization of 5-hydoxymethylcytosine in melanoma reveals major differences with nevus.Genes, chromosomes & cancer · 2020Article
- Advances in targeted therapy for malignant lymphoma.Signal transduction and targeted therapy · 2020Review
- GsmPlot: a web server to visualize epigenome data in NCBI.BMC bioinformatics · 2020Article
- Article
- TET1 contributes to allergic airway inflammation and regulates interferon and aryl hydrocarbon receptor signaling pathways in bronchial epithelial cells.Scientific reports · 2019Article
- Review
- Gene activation precedes DNA demethylation in response to infection in human dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis.Life science alliance · 2019Article
- TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells.Genome research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic mechanisms are believed to play key roles in the establishment of cell-specific transcription programs. Accordingly, the modified bases 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) have been observed in DNA of genomic regulatory regions such as enhancers, and oxidation of 5mC into 5hmC by Ten-eleven translocation (TET) proteins correlates with enhancer activation. However, the functional relationship between cytosine modifications and the chromatin architecture of enhancers remains elusive. To gain insights into their function, 5mC and 5hmC levels were perturbed by inhibiting DNA methyltransferases and TETs during differentiation of mouse embryonal carcinoma cells into neural progenitors, and chromatin characteristics of enhancers bound by the pioneer transcription factors FOXA1, MEIS1, and PBX1 were interrogated. In a large fraction of the tested enhancers, inhibition of DNA methylation was associated with a significant increase in monomethylation of H3K4, a characteristic mark of enhancer priming. In addition, at some specific enhancers, 5mC oxidation by TETs facilitated chromatin opening, a process that may stabilize MEIS1 binding to these genomic regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.