Evidence map›Paper›PMID 28396503›Full record

ArticleGenetics2017

Correlation of Meiotic DSB Formation and Transcription Initiation Around Fission Yeast Recombination Hotspots.

Shintaro Yamada, Mika Okamura, Arisa Oda, Hiroshi Murakami, Kunihiro Ohta, Takatomi Yamada

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Shintaro YamadaDepartment of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 153-8902, Japan.
Mika OkamuraDepartment of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 153-8902, Japan.
Arisa OdaDepartment of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 153-8902, Japan.
Hiroshi MurakamiDepartment of Biological Sciences, Faculty of Science and Engineering, Chuo University, Tokyo 112-8551, Japan.
Kunihiro OhtaDepartment of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 153-8902, Japan.
Takatomi YamadaDepartment of Biological Sciences, Faculty of Science and Engineering, Chuo University, Tokyo 112-8551, Japan tyamada@bio.chuo-u.ac.jp.
The University of Tokyo · JPChuo University · JPTokyo University of the Arts · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meiotic homologous recombination, a critical event for ensuring faithful chromosome segregation and creating genetic diversity, is initiated by programmed DNA double-strand breaks (DSBs) formed at recombination hotspots. Meiotic DSB formation is likely to be influenced by other DNA-templated processes including transcription, but how DSB formation and transcription interact with each other has not been understood well. In this study, we used fission yeast to investigate a possible interplay of these two events. A group of hotspots in fission yeast are associated with sequences similar to the cyclic AMP response element and activated by the ATF/CREB family transcription factor dimer Atf1-Pcr1. We first focused on one of those hotspots,

Indexed as

DNA Breaks, Double-StrandedRecombination, GeneticActivating Transcription Factor 1Activating Transcription FactorsCyclic AMP Response Element-Binding ProteinHomologous RecombinationMeiosisPhosphoproteinsSchizosaccharomycesSchizosaccharomyces pombe ProteinsActivating Transcription Factor 1Activating Transcription Factorsatf1 protein, S pombeCyclic AMP Response Element-Binding ProteinPcr1 protein, S pombePhosphoproteinsSchizosaccharomyces pombe ProteinschromatinDNA double-strand break formationmeiosismeiotic recombinationtranscription

Identifiers

PMID28396503
PMCPMC5499187
OpenAlexW2607445811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.