ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2017
Heterogeneities in the case fatality ratio in the West African Ebola outbreak 2013-2016.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical factors associated with mortality in ebola virus disease: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- A systematic review and meta-analysis of patient data from the West Africa (2013-16) Ebola virus disease epidemic.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2019Pooled it
- Psychological Components of Disease Stigma Across Illnesses: Associations with Cultural and Personal Factors.Behavioral sciences (Basel, Switzerland) · 2026Article
- Development of two-dimension epidemic prediction model.Infectious Disease Modelling · 2025Article
- Ebola Virus Disease: Uniquely Challenging Among the Viral Hemorrhagic Fevers.Open forum infectious diseases · 2025Review
- Health and economic impacts of Lassa vaccination campaigns in West Africa.Nature medicine · 2024Article
- How mathematical modelling can inform outbreak response vaccination.BMC infectious diseases · 2024Review
- Ebola disease outbreak caused by the Sudan virus in Uganda, 2022: a descriptive epidemiological study.The Lancet. Global health · 2024Article
- Delayed treatment of cynomolgus macaques with a FVM04/CA45 monoclonal antibody cocktail provides complete protection against lethal Sudan virus infection.Journal of virology · 2024Article
- Rhabdomyolysis, Acute Kidney Injury, and Mortality in Ebola Virus Disease: Retrospective Analysis of Cases From the Eastern Democratic Republic of the Congo, 2019.The Journal of infectious diseases · 2024Article
- Sudan Virus Disease among Health Care Workers, Uganda, 2022.The New England journal of medicine · 2024Article
- Serological evidence of zoonotic filovirus exposure among bushmeat hunters in Guinea.Nature communications · 2024Article
- A new method for accurate calculation of case fatality rates during a pandemic: Mathematical deduction based on population-level big data.Infectious medicine · 2023Article
- Ebola virus: a new concern, its virological characteristics, diagnosis, present condition, and treatment during the ongoing SARS-CoV-2 omicron variant - correspondence.Annals of medicine and surgery (2012) · 2023Article
- Impacts of observation frequency on proximity contact data and modeled transmission dynamics.PLoS computational biology · 2023Article
- Article
- THE INTERGENERATIONAL MORTALITY TRADE-OFF OF COVID-19 LOCKDOWN POLICIES.International economic review · 2022Article
- Inferring the reproduction number using the renewal equation in heterogeneous epidemics.Journal of the Royal Society, Interface · 2022Article
- The SARS-CoV-2 pandemic: remaining uncertainties in our understanding of the epidemiology and transmission dynamics of the virus, and challenges to be overcome.Interface focus · 2021Review
- COVID-19 in WHO African Region: Account and Correlation of Epidemiological Indices with Some Selected Health-related Metrics.Ethiopian journal of health sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
Abstract
The 2013-2016 Ebola outbreak in West Africa is the largest on record with 28 616 confirmed, probable and suspected cases and 11 310 deaths officially recorded by 10 June 2016, the true burden probably considerably higher. The case fatality ratio (CFR: proportion of cases that are fatal) is a key indicator of disease severity useful for gauging the appropriate public health response and for evaluating treatment benefits, if estimated accurately. We analysed individual-level clinical outcome data from Guinea, Liberia and Sierra Leone officially reported to the World Health Organization. The overall mean CFR was 62.9% (95% CI: 61.9% to 64.0%) among confirmed cases with recorded clinical outcomes. Age was the most important modifier of survival probabilities, but country, stage of the epidemic and whether patients were hospitalized also played roles. We developed a statistical analysis to detect outliers in CFR between districts of residence and treatment centres (TCs), adjusting for known factors influencing survival and identified eight districts and three TCs with a CFR significantly different from the average. From the current dataset, we cannot determine whether the observed variation in CFR seen by district or treatment centre reflects real differences in survival, related to the quality of care or other factors or was caused by differences in reporting practices or case ascertainment.This article is part of the themed issue 'The 2013-2016 West African Ebola epidemic: data, decision-making and disease control'.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.