Evidence map›Paper›PMID 28396421›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Antigenicity-defined conformations of an extremely neutralization-resistant HIV-1 envelope spike.

Yongfei Cai, Selen Karaca-Griffin, Jia Chen, Sai Tian, Nicholas Fredette, Christine E Linton, Sophia Rits-Volloch, Jianming Lu, Kshitij Wagh, James Theiler and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Incompletely closed HIV-1Npj viruses · 2025
    Article
  3. Review
  4. Broadly neutralizing monoclonal antibodies for HIV prevention.Journal of the International AIDS Society · 2021
    Article
  5. Article
  6. Article
  7. Article
  8. Molecular Mechanism of HIV-1 Entry.Trends in microbiology · 2019
    Review
  9. Article
  10. Article
  11. Neutralization tiers of HIV-1.Current opinion in HIV and AIDS · 2018
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Yongfei CaiLaboratory of Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.
Selen Karaca-GriffinGlaxoSmithKline Vaccines, Rockville, MD 20850.
Jia ChenLaboratory of Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.
Sai TianGlaxoSmithKline Vaccines, Rockville, MD 20850.
Nicholas FredetteCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Christine E LintonGlaxoSmithKline Vaccines, Rockville, MD 20850.
Sophia Rits-VollochLaboratory of Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.
Jianming LuCodex BioSolutions, Inc., Gaithersburg, MD 20879.
Kshitij WaghTheoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545.
James TheilerTheoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545.
Bette KorberTheoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545.
Michael S SeamanCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Stephen C HarrisonLaboratory of Molecular Medicine, Boston Children's Hospital, Boston, MA 02115; bchen@crystal.harvard.edu harrison@crystal.harvard.edu.
Andrea CarfiGlaxoSmithKline Vaccines, Rockville, MD 20850.
Bing ChenLaboratory of Molecular Medicine, Boston Children's Hospital, Boston, MA 02115; bchen@crystal.harvard.edu harrison@crystal.harvard.edu.
GlaxoSmithKline (United States) · USLos Alamos National Laboratory · USBeth Israel Deaconess Medical Center · USBoston Children's Museum · USBoston Children's Hospital · USCodex Biosolutions (United States) · USHarvard University · USHoward Hughes Medical Institute · US

Funding

Virus biology scientific research support componentUM1AI100645 · NIAID · DUKE UNIVERSITY · PI KELSOE, GARNETT H · 2012 to 2018
$204.7M
Structure-function studies of the membrane-interacting domains of HIV-1 Env spikeR01AI127193 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHEN, BING, HARRISON, STEPHEN COPLAN · 2016 to 2025
$8.4M
Crystallographic studies of intact and fully glycosylated HIV-1 gp120R01AI106488 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHEN, BING · 2013 to 2017
$2.2M
Small-Molecule Fusion Inhibitors Targeting a Fusion Intermediate State of HIV-1 gR56AI112489 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHEN, BING · 2014 to 2014
$440k
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI106488NIAID NIH HHS R01 AI127193NIAID NIH HHS R56 AI112489NIAID NIH HHS UM1 AI100645
6 · The paper itself

Abstract

The extraordinary genetic diversity of the HIV-1 envelope spike [Env; trimeric (gp160)

Indexed as

Antibodies, MonoclonalAntibodies, NeutralizingAntigensEpitopesHEK293 CellsHIV-1HIV AntibodiesHIV Envelope Protein gp120HIV Envelope Protein gp160HumansProtein ConformationAntibodies, MonoclonalAntibodies, NeutralizingAntigensEpitopesHIV AntibodiesHIV Envelope Protein gp120HIV Envelope Protein gp160HIV-1 gp160neutralizing antibodiesvaccine design

Identifiers

PMID28396421
PMCPMC5410843
OpenAlexW2606163836

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.