Evidence map›Paper›PMID 28396406›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

David Zemmour, Alvin Pratama, Scott M Loughhead, Diane Mathis, Christophe Benoist

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 1 synthesis or guideline pooled it, 170 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Non-coding RNA Networks in Infection.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  13. Article
  14. Review
  15. Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Review
  17. Review
  18. A bibliometrics study on the status quo and hot topics of pathogenesis of psoriasis based on Web of Science.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  19. Review
  20. Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

David ZemmourDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115.
Alvin PratamaDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115.
Scott M LoughheadDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115.
Diane MathisDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115 cbdm@hms.harvard.edu.
Christophe BenoistDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115 cbdm@hms.harvard.edu.
Harvard University · US

Funding

Naive T cell homeostasis: Treg selection and survivalR37AI051530 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2009 to 2018
$4.1M
Naive T cell survival: TCR and IL-7R signal interplayR01AI051530 · NIAID · JOSLIN DIABETES CENTER · PI BENOIST, CHRISTOPHE O. · 2002 to 2009
$2.4M
Specification of Treg cells: FOXP3 functional facetsR01AI116834 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2015 to 2019
$2.3M
Special BD LSRFortessaS10OD021740 · OD · JOSLIN DIABETES CENTER · PI SERWOLD, THOMAS F · 2016 to 2016
$363k
NIAID NIH HHS R01 AI051530NIAID NIH HHS R01 AI116834NIAID NIH HHS R37 AI051530NIH HHS S10 OD021740
6 · The paper itself

Abstract

A combination of transcription factors, enhancers, and epigenetic marks determines the expression of the key transcription factor FoxP3 in regulatory T cells (Tregs). Adding an additional layer of complexity, the long noncoding RNA (lncRNA)

Indexed as

AutoimmunityAnimalsForkhead Transcription FactorsGene Expression RegulationGenome, HumanHumansMiceMice, KnockoutRNA, Long NoncodingT-Lymphocytes, RegulatoryForkhead Transcription FactorsFOXP3 protein, humanFoxp3 protein, mouseRNA, Long NoncodingautoimmunityFoxp3gene regulationlong noncoding RNAregulatory T cells

Identifiers

PMID28396406
PMCPMC5410798
OpenAlexW2605741026

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.