Evidence map›Paper›PMID 28396319›Full record

ArticleInfection and immunity2017

Host Resistance to Plasmodium-Induced Acute Immune Pathology Is Regulated by Interleukin-10 Receptor Signaling.

Carla Claser, J Brian De Souza, Samuel G Thorburn, Georges Emile Grau, Eleanor M Riley, Laurent Rénia, Julius C R Hafalla

Open access · hybridAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Regulatory T cell memory: implications for malaria.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Vaccination with anFrontiers in immunology · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Frontiers in immunology · 2019
    Article
  10. Species Specificity of Type III Interferon Activity and Development of a Sensitive Luciferase-Based Bioassay for Quantitation of Mouse Interferon-λ.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2018
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Carla ClaserLaboratory of Pathogen Immunobiology, Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore.
J Brian De SouzaDivision of Infection and Immunity, University College London Medical School, London, United Kingdom.
Samuel G ThorburnImmunology and Infection Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Georges Emile GrauVascular Immunology Unit, Department of Pathology, School of Medical Sciences, Bosch Institute, The University of Sydney, Camperdown, New South Wales, Australia.
Eleanor M RileyImmunology and Infection Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Laurent RéniaLaboratory of Pathogen Immunobiology, Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore.
Julius C R HafallaImmunology and Infection Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom Julius.Hafalla@lshtm.ac.uk.
London School of Hygiene & Tropical Medicine · GBAgency for Science, Technology and Research · SGUniversity College London · GBUniversity of Sydney · AU

Funding

Medical Research CouncilNational Centre for the Replacement, Refinement and Reduction of Animals in Research NC/L000601/1
6 · The paper itself

Abstract

The resolution of malaria infection is dependent on a balance between proinflammatory and regulatory immune responses. While early effector T cell responses are required for limiting parasitemia, these responses need to be switched off by regulatory mechanisms in a timely manner to avoid immune-mediated tissue damage. Interleukin-10 receptor (IL-10R) signaling is considered to be a vital component of regulatory responses, although its role in host resistance to severe immune pathology during acute malaria infections is not fully understood. In this study, we have determined the contribution of IL-10R signaling to the regulation of immune responses during

Indexed as

AnimalsAntibodies, BlockingAntibodies, NeutralizingBrainCD8-Positive T-LymphocytesErythrocytesFemaleInterferon-gammaLiverLymphocyte ActivationMalaria, CerebralMiceMice, Inbred BALB CMice, Inbred C57BLParasitemiaPlasmodium bergheiAntibodies, BlockingAntibodies, NeutralizingInterferon-gammaReceptors, Interleukin-10IFN-γIL-10immunopathologymalariaPlasmodium bergheiT cells

Identifiers

PMID28396319
PMCPMC5442633
OpenAlexW2606342359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.