Evidence map›Paper›PMID 28396199›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2017

Hypoxia Response Element-Regulated MMP-9 Promotes Neurological Recovery via Glial Scar Degradation and Angiogenesis in Delayed Stroke.

Hongxia Cai, Yuanyuan Ma, Lu Jiang, Zhihao Mu, Zhen Jiang, Xiaoyan Chen, Yongting Wang, Guo-Yuan Yang, Zhijun Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 74 citations in OpenAlex.

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  5. Impacts of Oxylipins on ischemic stroke: from pathophysiology to clinical phenotypes.Metabolomics : Official journal of the Metabolomic Society · 2025
    Review
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  9. Observational
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  14. Progranulin released from microglial lysosomes reduces neuronal ferroptosis after cerebral ischemia in mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  15. Endothelial progenitor cell transplantation attenuates synaptic loss associated with enhancing complement receptor 3-dependent microglial/macrophage phagocytosis in ischemic mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hongxia CaiDepartment of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Department of Neurology, Yangzhou University Affiliated Hospital, Yangzhou No. 1 People's Hospital, Jiangsu Province, 225000, China.
Yuanyuan MaDepartment of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Neuroscience and Neuroengineering Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Lu JiangNeuroscience and Neuroengineering Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Zhihao MuDepartment of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Neuroscience and Neuroengineering Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Zhen JiangDepartment of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Neuroscience and Neuroengineering Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Xiaoyan ChenNeuroscience and Neuroengineering Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Yongting WangNeuroscience and Neuroengineering Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Guo-Yuan YangDepartment of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Neuroscience and Neuroengineering Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China. Electronic address: gyyang0626@gmail.com.
Zhijun ZhangNeuroscience and Neuroengineering Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China. Electronic address: zhangzhij@gmail.com.
Shanghai Jiao Tong University · CNRuijin Hospital · CNYangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Matrix metalloproteinase 9 (MMP-9) plays a beneficial role in the delayed phase of middle cerebral artery occlusion (MCAO). However, the mechanism is obscure. Here, we constructed hypoxia response element (HRE)-regulated MMP-9 to explore its effect on glial scars and neurogenesis in delayed ischemic stroke. Adult male Institute of Cancer Research (ICR) mice underwent MCAO and received a stereotactic injection of lentivirus carrying HRE-MMP-9 or normal saline (NS)/lentivirus-GFP 7 days after ischemia. We found that HRE-MMP-9 improved neurological outcomes, reduced ischemia-induced brain atrophy, and degraded glial scars (p < 0.05). Furthermore, HRE-MMP-9 increased the number of microvessels in the peri-infarct area (p < 0.001), which may have been due to the accumulation of endogenous endothelial progenitor cells (EPCs) in the peri-infarct area after glial scar degradation. Finally, HRE-MMP-9 increased the number of bromodeoxyuridine-positive (BrdU

Indexed as

Response ElementsAnimalsAstrocytesAtrophyBrainCell MovementDisease Models, AnimalExtracellular MatrixHypoxiaInfarction, Middle Cerebral ArteryMaleMatrix Metalloproteinase 9MiceNeovascularization, PhysiologicNeurogenesisNeurogliaMatrix Metalloproteinase 9angiogenesisglial scarHRE-MMP-9neurogenesisstroke

Identifiers

PMID28396199
PMCPMC5474960
OpenAlexW2603630913

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.