Evidence map›Paper›PMID 28396118›Full record

ArticleKidney international2017

Superoxide and hydrogen peroxide counterregulate myogenic contractions in renal afferent arterioles from a mouse model of chronic kidney disease.

Lingli Li, En Yin Lai, Zaiming Luo, Glenn Solis, Kathy K Griendling, W Robert Taylor, Pedro A Jose, Anton Wellstein, William J Welch, Christopher S Wilcox

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Lingli LiDivision of Nephrology and Hypertension, and Hypertension Center, Georgetown University, Washington, DC, USA.
En Yin LaiDivision of Nephrology and Hypertension, and Hypertension Center, Georgetown University, Washington, DC, USA; Department of Physiology, Zhejiang University School of Medicine, Hangzhou, China.
Zaiming LuoDivision of Nephrology and Hypertension, and Hypertension Center, Georgetown University, Washington, DC, USA.
Glenn SolisDivision of Nephrology and Hypertension, and Hypertension Center, Georgetown University, Washington, DC, USA.
Kathy K GriendlingDepartment of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA.
W Robert TaylorDepartment of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA.
Pedro A JoseDivision of Renal Diseases & Hypertension, Department of Medicine and Department of Pharmacology and Physiology, George Washington University; Washington, DC, USA.
Anton WellsteinLombardi Cancer Center, Georgetown University, Washington, DC, USA.
William J WelchDivision of Nephrology and Hypertension, and Hypertension Center, Georgetown University, Washington, DC, USA.
Christopher S WilcoxDivision of Nephrology and Hypertension, and Hypertension Center, Georgetown University, Washington, DC, USA. Electronic address: wilcoxch@georgetown.edu.
Georgetown University · USEmory University · USGeorge Washington University · US

Funding

Renal Vascular Oxidative Stress in HypertensionP01HL068686 · NHLBI · GEORGETOWN UNIVERSITY · PI JOSE, PEDRO A., SANDBERG, KATHRYN L · 2001 to 2017
$28.8M
REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANER37DK036079 · NIDDK · GEORGETOWN UNIVERSITY · PI WILCOX, CHRISTOPHER S · 2003 to 2012
$5.2M
NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUSR01DK049870 · NIDDK · GEORGETOWN UNIVERSITY · PI WILCOX, CHRISTOPHER S · 1994 to 2014
$4.6M
REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANER01DK036079 · NIDDK · UNIVERSITY OF FLORIDA · PI WILCOX, CHRISTOPHER S · 1986 to 2002
$830k
NHLBI NIH HHS P01 HL068686NIDDK NIH HHS R01 DK036079NIDDK NIH HHS R01 DK049870NIDDK NIH HHS R37 DK036079
6 · The paper itself

Abstract

Myogenic contractions protect kidneys from barotrauma but are impaired in chronic kidney disease (CKD). Since myogenic contractions are enhanced by superoxide but impaired by hydrogen peroxide, we tested the hypothesis that they are counterregulated by superoxide and H

Indexed as

AnimalsArteriolesCatalaseCyclic N-OxidesDisease Models, AnimalHumansHydrogen PeroxideKidneyMaleMiceMice, Inbred C57BLMice, TransgenicMicroscopy, FluorescenceMitochondrial ProteinsMuscle, Smooth, VascularNADPH Oxidase 2Catalasecatalase-polyethylene glycolCybb protein, mouseCyclic N-OxidesHydrogen PeroxideMitochondrial Proteinsmitogenin 1 protein, mouseNADPH Oxidase 2NADPH Oxidase 4NADPH Oxidasesneutrophil cytosolic factor 1Nox4 protein, mouseNuclear ProteinsPolyethylene GlycolsSpin LabelsSuperoxide DismutaseSuperoxidestempoloxidative stressreduced renal massrenal autoregulationtempol

Identifiers

PMID28396118
PMCPMC12825038
OpenAlexW2604348152

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.