ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2017
Association of Unilateral Renal Agenesis With Adverse Outcomes in Pregnancy: A Matched Cohort Study.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Hyperaldosteronism secondary to renal agenesis: An unusual cause for hypertension in pregnancy.Pregnancy hypertension · 2024Article
- Protein Misfolding in Pregnancy: Current Insights, Potential Mechanisms, and Implications for the Pathogenesis of Preeclampsia.Molecules (Basel, Switzerland) · 2024Review
- Risk stratification for children with a solitary functioning kidney.Pediatric nephrology (Berlin, Germany) · 2021Article
- Nephron-deficient HSRA rats exhibit renal injury with age but have limited renal damage from streptozotocin-induced hyperglycemia.American journal of physiology. Renal physiology · 2021Article
- Clinical Management of Children with a Congenital Solitary Functioning Kidney: Overview and Recommendations.European urology open science · 2021Review
- Preeclampsia and Kidney Disease: Deciphering Cause and Effect.Current hypertension reports · 2020Review
- Pregnancy in women known to be living with a single kidney.Obstetric medicine · 2019Article
- Acute IgA-Dominant Glomerulonephritis Associated with Syphilis Infection in a Pregnant Teenager: A New Disease Association.Journal of clinical medicine · 2019Article
- Risk of adverse maternal and fetal outcomes during pregnancy in living kidney donors: A matched cohort study.Clinical transplantation · 2019Article
- Risk of Preeclampsia and Pregnancy Complications in Women With a History of Acute Kidney Injury.Hypertension (Dallas, Tex. : 1979) · 2018Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundData regarding the effect of a solitary kidney during pregnancy have come from studies of living kidney donors. We evaluated the risk for adverse pregnancy outcomes in women with a single kidney from renal agenesis. STUDY
designMatched cohort study. SETTING &
participantsUsing data from 7,079 childbirths from an integrated health care delivery system from 1996 through 2015, we identified births from women with renal agenesis. Only first pregnancies and singleton births were included. After excluding those with diabetes and kidney disease, 200 women with renal agenesis were matched 1:4 by age (within 2 years), race, and history of hypertension to women with 2 kidneys. PREDICTOR: Renal agenesis defined by International Classification of Diseases, Ninth Revision (ICD-9) codes prior to pregnancy. OUTCOMES: The primary outcome was adverse maternal outcomes, including preterm delivery, delivery by cesarean section, preeclampsia/eclampsia, and hospital length of stay. Adverse neonatal end points were considered as a secondary outcome and included low birth weight (<2,500g) and infant death/transfer to acute inpatient facility.
resultsMean gestational age at delivery was 37.9±2.1 weeks for women with renal agenesis compared to 38.6±1.8 weeks for women with 2 kidneys. Compared with women with 2 kidneys, those with renal agenesis had increased risk for preterm delivery (OR, 2.88; 95% CI, 1.86-4.45), delivery by cesarean section (OR, 2.11; 95% CI, 1.49-2.99), preeclampsia/eclampsia (OR, 2.41; 95% CI, 1.23-4.72), and length of stay longer than 3 days (OR, 1.81; 95% CI, 1.18-2.78). Renal agenesis was not significantly associated with increased risk for infant death/transfer to acute facility (OR, 2.60; 95% CI, 0.57-11.89) or low birth weight after accounting for preterm delivery (OR, 2.11; 95% CI, 0.76-5.88). LIMITATIONS: Renal agenesis was identified by ICD-9 code, not by imaging of the abdomen.
conclusionWomen with unilateral renal agenesis have a higher risk for adverse outcomes in pregnancy.
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