Evidence map›Paper›PMID 28396025›Full record

ArticleThe Journal of pediatrics2017

Prophylactic Indomethacin Compared with Delayed Conservative Management of the Patent Ductus Arteriosus in Extremely Preterm Infants: Effects on Neonatal Outcomes.

Melissa Liebowitz, Ronald I Clyman

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06064825 (Long Term Follow-up of the TREOCAPA), which is not on this map. Cited by 44 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 5 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06064825 recruitingnot on this mapstarted 2023, after this paper: background citation

Long Term Follow-up of the TREOCAPA (Prophylactic TREatment Of the duCtus Arteriosus in Preterm Infants by Acetaminophen) Study (TREOCAPA-LT)

TypeobservationalSponsorInstitut National de la Santé Et de la Recherche Médicale, FranceRan2023 to 2027Enrolled500ConditionsPatency of the Ductus Arteriosus Acetaminophen Extreme PrematurityArms2 year follow-up of neurodevelopment using a parental questionnaire
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 5 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. A FAR-Out approach for evaluating the impact of clinical practice changes on severe intracranial hemorrhage in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  8. Article
  9. Article
  10. Prophylactic indomethacin and the risk of serious pulmonary hemorrhages in preterm infants less than 28 weeks' gestation.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  11. Article
  12. Review
  13. Observational
  14. Prophylactic indomethacin, antenatal betamethasone, and the risk of intestinal perforation in infants <28 weeks' gestation.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Observational
  15. Article
  16. Article
  17. Effects of prophylactic indomethacin on intraventricular hemorrhage and adverse outcomes in neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2022
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Melissa LiebowitzDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA.
Ronald I ClymanDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA. Electronic address: clymanr@peds.ucsf.edu.
University of California, San Francisco · US

Funding

Genes contributing to patent ductus arteriosus susceptibility in preterm newbornsR01HL109199 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CLYMAN, RONALD I · 2011 to 2014
$3.0M
Graduate Training Program in Neonatal-Perinatal Translational ResearchT32HD071860 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROWITCH, DAVID H · 2012 to 2016
$969k
NHLBI NIH HHS R01 HL109199NICHD NIH HHS T32 HD071860
6 · The paper itself

Abstract

objectiveTo determine whether prophylactic indomethacin (PINDO) has more or less morbidity than delayed conservative management of the moderate-to-large patent ductus arteriosus (PDA). STUDY

designWe performed a prospective double cohort controlled study of infants delivered at ≤27

resultsThe incidence of moderate-to-large PDA on day 7 and duration of exposure to moderate-to-large PDA were significantly less in the PINDO epoch (incidence = 10%, median = 2 days) than the conservative epoch (incidence = 67%, median = 14 days). Ligation rates were low in both epochs (PINDO = 14%, conservative = 5%). In multivariate analyses, PINDO infants had a significantly lower incidence of bronchopulmonary dysplasia (BPD) (risk ratio = 0.68, CI: 0.46-0.89) and BPD or death (risk ratio= 0.78, CI: 0.62-0.95) than conservative infants. There were no differences between the epochs in death, intraventricular hemorrhage grades 3 and 4, necrotizing enterocolitis, or retinopathy of prematurity receiving treatment. The effects of PINDO on BPD and BPD or death were no longer significant when analyses were adjusted for presence of a moderate-to-large PDA on day 7. The significant effects of PINDO were independent of whether or not a ligation was performed.

conclusionsPINDO decreases BPD and BPD or death compared with delayed conservative PDA management. These effects are mediated by closure of the PDA.

Indexed as

Bronchopulmonary DysplasiaCohort StudiesConservative TreatmentCyclooxygenase InhibitorsDuctus Arteriosus, PatentEchocardiographyFemaleHumansIncidenceIndomethacinInfant, Extremely PrematureInfant, NewbornMaleProspective StudiesTreatment OutcomeCyclooxygenase InhibitorsIndomethacinbronchopulmonary dysplasianecrotizing enterocolitisnewbornpremature birthretinopathy of prematurity

Identifiers

PMID28396025
PMCPMC5533630
OpenAlexW2604208305

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.