ArticleThe Journal of investigative dermatology2017
Epidermal Barrier Protects against Age-Associated Systemic Inflammation.
Article in The Journal of investigative dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Review
- Chamazulene Induces Metabolic Reprogramming and Mitigates Inflammation in Photoaged Skin: PPARα/γ as Potential Regulators.Antioxidants (Basel, Switzerland) · 2025Article
- Exploring melatonin's signalling pathways in the protection against age-related skin deterioration.Pharmacological reports : PR · 2025Review
- A Triple-Precursor Blend as a Topical Solution to Protect the Skin Against Environmental Damage.Biology · 2025Article
- Effect of pyrroloquinoline quinone on skin aging in Bmi-1 KO mice and underlying mechanisms.PloS one · 2025Article
- Review
- Dihydroavenanthramide D Enhances Skin Barrier Function through Upregulation of Epidermal Tight Junction Expression.Current issues in molecular biology · 2024Article
- Fibroblast Yap/Taz Signaling in Extracellular Matrix Homeostasis and Tissue Fibrosis.Journal of clinical medicine · 2024Review
- Emerging Perspectives of YAP/TAZ in Human Skin Epidermal and Dermal Aging.Annals of dermatology · 2024Review
- Interaction between the microbiota and the skin barrier in aging skin: a comprehensive review.Frontiers in physiology · 2024Review
- Human Skin Aging and the Anti-Aging Properties of Retinol.Biomolecules · 2023Review
- The Skin and Inflamm-Aging.Biology · 2023Review
- A Retrospective Review of Chronic Non-Communicable Dermatoses Among Older Adults at a Tertiary Healthcare Facility in Southwestern Nigeria.Dermatology practical & conceptual · 2023Article
- Stable analogs of 13‑hydroxy-9,10-trans-epoxy-(11E)-octadecenoate (13,9-HEL), an oxidized derivative of linoleic acid implicated in the epidermal skin barrier.Prostaglandins, leukotrienes, and essential fatty acids · 2021Article
- Autophagic Control of Skin Aging.Frontiers in cell and developmental biology · 2019Review
Corrections and comments
- Comment on
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin provides barrier protection for the body, but aging disrupts epidermal barrier function. Hu et al. show that disruption of the epidermal barrier increases serum cytokine levels partly because of increased cytokine production by the skin. They then show that restoring epidermal barrier function in aged mice reduces circulating levels of proinflammatory cytokines.
Indexed as
Identifiers
28395899What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.