Evidence map›Paper›PMID 28395898›Full record

ArticleThe Journal of investigative dermatology2017

p63 Adjusts Sugar Taste of Epidermal Layers.

Ivano Amelio, Gerry Melino, Eleonora Candi

Open access · greenAbstract readComment
PubMed Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. p63 Is a Promising Marker in the Diagnosis of Unusual Skin Cancer.International journal of molecular sciences · 2019
    Review
  5. Master regulatory role of p63 in epidermal development and disease.Cellular and molecular life sciences : CMLS · 2018
    Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Ivano AmelioMedical Research Council, Toxicology Unit, Leicester, UK. Electronic address: ia119@le.ac.uk.
Gerry MelinoMedical Research Council, Toxicology Unit, Leicester, UK; Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", 00133 Rome, Italy.
Eleonora CandiDepartment of Experimental Medicine and Surgery, University of Rome "Tor Vergata", 00133 Rome, Italy; Biochemistry Laboratory, Istituto Dermopatico Immacolata (IDI-IRCCS), 00100 Rome, Italy.
University of Rome Tor Vergata · ITMedical Research Council · GB

Funding

Medical Research Council MC_U132670600
6 · The paper itself

Abstract

p63 is a master regulator of epidermal biology, sustaining stemness and renewal capacity of the proliferating keratinocyte compartment. Hamanaka and Mutlu propose that p63 regulates the keratinocyte proliferation/differentiation switch by affecting the cellular glycolic rate through a direct transcriptional regulation of the metabolic enzyme PFKFB3. This finding sheds light on mechanisms underlining p63 function in the skin and suggests a role for energetic metabolism in epidermal biology.

Indexed as

Gene Expression RegulationCell DifferentiationCell ProliferationCells, CulturedDietary CarbohydratesEpidermisGlycolysisHumansKeratinocytesMembrane ProteinsSensitivity and SpecificityTasteCKAP4 protein, humanDietary CarbohydratesMembrane Proteins

Identifiers

PMID28395898
OpenAlexW2604603478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.