ArticleEpidemics2017
The impact of stratified immunity on the transmission dynamics of influenza.
Article in Epidemics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 45 citations in OpenAlex.
- Estimating the Severity Profile of Enterovirus A71 Infections in Children: A Bayesian Synthesis Framework.American journal of epidemiology · 2019Trial
- Influenza A/H3N2 epidemiology in England during the 2025 to 2026 season: a mathematical modelling study.Communications health · 2026Article
- Effects of repeated influenza vaccination and infection on durable seroprotection in healthcare workers.NPJ vaccines · 2025Article
- Serodynamics: A primer and synthetic review of methods for epidemiological inference using serological data.Epidemics · 2024Review
- Effects of boosting and waning in highly exposed populations on dengue epidemic dynamics.Science translational medicine · 2023Article
- Observational
- Impacts of social distancing, rapid antigen test and vaccination on the Omicron outbreak during large temperature variations in Hong Kong: A modelling study.Journal of infection and public health · 2022Article
- Virological Surveillance of Influenza in the eight epidemic seasons after the 2009 pandemic in Emilia-Romagna (Northern Italy).Acta bio-medica : Atenei Parmensis · 2019Article
- Characterising antibody kinetics from multiple influenza infection and vaccination events in ferrets.PLoS computational biology · 2019Article
- Age-specific differences in the dynamics of protective immunity to influenza.Nature communications · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Although empirical studies show that protection against influenza infection in humans is closely related to antibody titres, influenza epidemics are often described under the assumption that individuals are either susceptible or not. Here we develop a model in which antibody titre classes are enumerated explicitly and mapped onto a variable scale of susceptibility in different age groups. Fitting only with pre- and post-wave serological data during 2009 pandemic in Hong Kong, we demonstrate that with stratified immunity, the timing and the magnitude of the epidemic dynamics can be reconstructed more accurately than is possible with binary seropositivity data. We also show that increased infectiousness of children relative to adults and age-specific mixing are required to reproduce age-specific seroprevalence observed in Hong Kong, while pre-existing immunity in the elderly is not. Overall, our results suggest that stratified immunity in an aged-structured heterogeneous population plays a significant role in determining the shape of influenza epidemics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.