ArticleAnalytica chimica acta2017
A novel near-infrared fluorescent probe for sensitive detection of β-galactosidase in living cells.
Article in Analytica chimica acta, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer.Science (New York, N.Y.) · 2026Article
- β-galactosidase Dynamic Monitoring in Cellular Senescence Process with a Novel Activatable Fluorescence Probe.Journal of fluorescence · 2026Article
- Towards precision medicine using biochemically triggered cleavable conjugation.Communications chemistry · 2025Review
- Emerging insights in senescence: pathways from preclinical models to therapeutic innovations.npj aging · 2024Review
- Whole-Cell Biosensor for Iron Monitoring as a Potential Tool for Safeguarding Biodiversity in Polar Marine Environments.Marine drugs · 2024Review
- Chemical Strategies for the Detection and Elimination of Senescent Cells.Accounts of chemical research · 2024Review
- Design strategies and biological applications of β-galactosidase fluorescent sensor in ovarian cancer research and beyond.RSC advances · 2024Review
- β-Galactosidase-Activatable Nile Blue-Based NIR Senoprobe for the Real-Time Detection of Cellular Senescence.Analytical chemistry · 2023Article
- Engineering molecular nanoprobes to target early atherosclerosis: Precise diagnostic tools and promising therapeutic carriers.Nanotheranostics · 2023Review
- Cellular senescence in cancer: clinical detection and prognostic implications.Journal of experimental & clinical cancer research : CR · 2022Review
- Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs.International journal of molecular sciences · 2022Review
- A general strategy to the intracellular sensing of glycosidases using AIE-based glycoclusters.Chemical science · 2021Article
- Cellular senescence in cancer: from mechanisms to detection.Molecular oncology · 2021Review
- Enzyme-activatable fluorescent probes for β-galactosidase: from design to biological applications.Chemical science · 2021Review
- A ratiometric fluorescent probe for the detection of β-galactosidase and its application.RSC advances · 2021Article
- Chromo-fluorogenic probes for β-galactosidase detection.Analytical and bioanalytical chemistry · 2021Review
- A Two-Photon Probe Based on Naphthalimide-Styrene Fluorophore for theAnalytical chemistry · 2021Article
- Article
- Targeting senescent cells in translational medicine.EMBO molecular medicine · 2019Review
- Detecting Zn(II) Ions in Live Cells with Near-Infrared Fluorescent Probes.Molecules (Basel, Switzerland) · 2019Article
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9 authors.
Funding
Abstract
A novel near-infrared fluorescent probe for β-galactosidase has been developed based on a hemicyanine skeleton, which is conjugated with a d-galactose residue via a glycosidic bond. The probe serves as a substrate of β-galactosidase and displays rapid and sensitive turn-on fluorescent responses to β-galactosidase in aqueous solution. A 12.8-fold enhancement of fluorescence intensity at 703 nm was observed after incubation of 10 nM of β-galactosidase with 5 μM probe for 10 min. The probe can sensitively detect as little as 0.1 nM of β-galactosidase and shows linear responses to the enzyme concentration below 1.4 nM. The kinetic study showed that the probe has high binding affinity to β-galactosidase with K
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