ArticleThe Journal of cell biology1988
Identification of new actin-associated polypeptides that are modified by viral transformation and changes in cell shape.
Article in The Journal of cell biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Transgelin Expression in Activated Cancer-Associated Fibroblasts Regulates Stromal Contractility and Promotes Colon Cancer Progression.Cancer medicine · 2026Article
- NRF2 promotes the migration of ovarian cancer cell lines by targeting TAGLN mediated epithelial-mesenchymal transition.Journal of ovarian research · 2025Article
- Differential Expression ofFrontiers in cell and developmental biology · 2021Article
- The transition of smooth muscle cells from a contractile to a migratory, phagocytic phenotype: direct demonstration of phenotypic modulation.The Journal of physiology · 2016Article
- Transgelin is a TGFβ-inducible gene that regulates osteoblastic and adipogenic differentiation of human skeletal stem cells through actin cytoskeleston organization.Cell death & disease · 2016Article
- Transgelin gene is frequently downregulated by promoter DNA hypermethylation in breast cancer.Clinical epigenetics · 2015Article
- Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer.Cancer science · 2013Article
- Sm22α transcription occurs at the early onset of the cardiovascular system and the intron 1 is dispensable for its transcription in smooth muscle cells during mouse development.International journal of physiology, pathophysiology and pharmacology · 2010Article
- Myosin, transgelin, and myosin light chain kinase: expression and function in asthma.American journal of respiratory and critical care medicine · 2009Article
- The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumour grade in human breast cancers.British journal of cancer · 2004Article
- The Saccharomyces cerevisiae calponin/transgelin homolog Scp1 functions with fimbrin to regulate stability and organization of the actin cytoskeleton.Molecular biology of the cell · 2003Article
- Analysis of SM22alpha-deficient mice reveals unanticipated insights into smooth muscle cell differentiation and function.Molecular and cellular biology · 2001Article
- Neonatal pulmonary hypertension prevents reorganisation of the pulmonary arterial smooth muscle cytoskeleton after birth.Journal of anatomy · 2000Article
- Purification and properties of transgelin: a transformation and shape change sensitive actin-gelling protein.The Journal of cell biology · 1993Article
- Gas2, a growth arrest-specific protein, is a component of the microfilament network system.The Journal of cell biology · 1992Article
- Comparative two-dimensional gel analysis and microsequencing identifies gelsolin as one of the most prominent downregulated markers of transformed human fibroblast and epithelial cells.The Journal of cell biology · 1990Article
- A polypeptide of 59 kDa is associated with bundles of cytoplasmic filaments in Neurospora crassa.The Biochemical journal · 1990Article
- Transformation of rabbit vascular smooth muscle cells by transfection with the early region of SV40 DNA.The American journal of pathology · 1990Article
- The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.The EMBO journal · 1989Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
By using a monoclonal antibody we have identified a new polypeptide doublet (C4h and C4l) of Mr approximately 21 kD and pI 8 and 7, respectively, that is associated with and (at the immunofluorescence level) uniformly distributed on actin filament bundles in rat, mouse, and other vertebrate species. C4 is absent in neurones, erythrocytes, and skeletal muscle but the epitope is evolutionarily conserved as it is present in invertebrates such as molluscs and crustaceans. C4h is not found in cells such as lymphocytes and oncogenically transformed mesenchymal cells where actin stress fiber bundles are reduced in number or absent. C4l, on the other hand, is always present. C4h expression can also be blocked by switching normal nontransformed mesenchymal cells from adherent to suspension culture. Reexpression of C4h occurs 24 h after these cells are returned to normal adherent culture conditions, but can be blocked by either actinomycin D or cycloheximide, suggesting that the expression of this epitope is regulated at the transcriptional level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.