Evidence map›Paper›PMID 28395138›Full record

ArticleChemical research in toxicology2017

Formation of S-[2-(N

Carl A Sedgeman, Yan Su, F Peter Guengerich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical research in toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. The abundant DNA adductThe Journal of biological chemistry · 2019
    Article
  3. Enzymatic bypass of an NThe Journal of biological chemistry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Carl A SedgemanDepartment of Biochemistry, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-0146, United States.
Yan SuDepartment of Biochemistry, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-0146, United States.
F Peter GuengerichDepartment of Biochemistry, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-0146, United States.ORCID 0000-0002-7458-3048
Vanderbilt University · US

Funding

BIOACTIVATION OF HALOGENATED HYDROCARBONSR01ES010546 · NIEHS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 2001 to 2020
$8.1M
Chemistry-Biology Interface Training GrantT32GM065086 · NIGMS · VANDERBILT UNIVERSITY · PI BACHMANN, BRIAN O, SULIKOWSKI, GARY ALLEN · 2002 to 2022
$7.0M
NIEHS NIH HHS R01 ES010546NIGMS NIH HHS T32 GM065086
6 · The paper itself

Abstract

1,2-Dibromoethane (DBE, ethylene dibromide) is a potent carcinogen due at least in part to its DNA cross-linking effects. DBE cross-links glutathione (GSH) to DNA, notably to sites on 2'-deoxyadenosine and 2'-deoxyguanosine ( Cmarik , J. L. , et al. ( 1991 ) J. Biol. Chem. 267 , 6672 - 6679 ). Adduction at the N6 position of 2'-deoxyadenosine (dA) had not been detected, but this is a site for the linkage of O

Indexed as

DNA AdductsDNA ReplicationAnimalsCattleChromatography, LiquidDNA-Directed DNA PolymeraseEthylene DibromideGlutathioneTandem Mass SpectrometryDNA AdductsDNA-Directed DNA PolymeraseEthylene DibromideGlutathione

Identifiers

PMID28395138
PMCPMC5768145
OpenAlexW2607151306

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.