Evidence map›Paper›PMID 28395116›Full record

ArticleBiometrics2017

Accelerated failure time models for semi-competing risks data in the presence of complex censoring.

Kyu Ha Lee, Virginie Rondeau, Sebastien Haneuse

Abstract read
In one paragraph

Article in Biometrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Review
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  5. Comment on "Lean body mass index and hypertension risk in men: a nationwide epidemiological cohort study".Hypertension research : official journal of the Japanese Society of Hypertension · 2026
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  12. Limitations of the cox proportional hazards model and alternative approaches in metachronous recurrence research.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024
    Article
  13. Article
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  15. Article
  16. Article
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  18. Causal inference for semi-competing risks data.Biostatistics (Oxford, England) · 2022
    Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kyu Ha LeeEpidemiology and Biostatistics Core, The Forsyth Institute, Cambridge, Massachusetts, U.S.A.ORCID 0000-0002-5313-8375
Virginie RondeauCentre INSERM U-897-Epidemiologie-Biostatistique, INSERM, Bordeaux, France.
Sebastien HaneuseDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, U.S.A.

Funding

Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
Clustered semi-competing risks analysis in quality of end-of-life care studiesR01CA181360 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI HANEUSE, SEBASTIEN · 2014 to 2017
$1.8M
NCI NIH HHS R01 CA181360NIA NIH HHS U01 AG006781
6 · The paper itself

Abstract

Statistical analyses that investigate risk factors for Alzheimer's disease (AD) are often subject to a number of challenges. Some of these challenges arise due to practical considerations regarding data collection such that the observation of AD events is subject to complex censoring including left-truncation and either interval or right-censoring. Additional challenges arise due to the fact that study participants under investigation are often subject to competing forces, most notably death, that may not be independent of AD. Towards resolving the latter, researchers may choose to embed the study of AD within the "semi-competing risks" framework for which the recent statistical literature has seen a number of advances including for the so-called illness-death model. To the best of our knowledge, however, the semi-competing risks literature has not fully considered analyses in contexts with complex censoring, as in studies of AD. This is particularly the case when interest lies with the accelerated failure time (AFT) model, an alternative to the traditional multiplicative Cox model that places emphasis away from the hazard function. In this article, we outline a new Bayesian framework for estimation/inference of an AFT illness-death model for semi-competing risks data subject to complex censoring. An efficient computational algorithm that gives researchers the flexibility to adopt either a fully parametric or a semi-parametric model specification is developed and implemented. The proposed methods are motivated by and illustrated with an analysis of data from the Adult Changes in Thought study, an on-going community-based prospective study of incident AD in western Washington State.

Indexed as

Bayes TheoremModels, StatisticalRisk FactorsAlgorithmsAlzheimer DiseaseComputer SimulationHumansWashingtonAccelerated failure time modelBayesian survival analysisIllness-death modelsInterval-censoringLeft-truncationSemi-competing risks

Identifiers

PMID28395116
PMCPMC8140291

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.