Evidence map›Paper›PMID 28395107›Full record

ArticleAmerican journal of clinical pathology2017

EBV-Positive B-Cell Proliferations of Varied Malignant Potential: 2015 SH/EAHP Workshop Report-Part 1.

Yasodha Natkunam, John R Goodlad, Amy Chadburn, Daphne de Jong, Dita Gratzinger, John K C Chan, Jonathan Said, Elaine S Jaffe

Open access · bronzeAbstract read
In one paragraph

Article in American journal of clinical pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 99 citations in OpenAlex.

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  13. New concepts in EBV-associated B, T, and NK cell lymphoproliferative disorders.Virchows Archiv : an international journal of pathology · 2023
    Review
  14. Article
  15. Age Related Immunosenescence Epstein-Barr Virus-positive Mucocutaneous Ulcer of the Palate Mimicking Medication-related Osteonecrosis of the Jaw.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 4 countries.

Yasodha NatkunamFrom the Stanford University School of Medicine, Stanford, CA.
John R GoodladHMDS, St James's University Hospital, Leeds, United Kingdom.
Amy ChadburnWeill Medical College of Cornell University, New York, NY.
Daphne de JongVU University Medical Center, Amsterdam, the Netherlands.
Dita GratzingerFrom the Stanford University School of Medicine, Stanford, CA.
John K C ChanQueen Elizabeth Hospital, Kowloon, Hong Kong.
Jonathan SaidUniversity of California Los Angeles Medical Center, Los Angeles.
Elaine S JaffeNational Institutes of Health, Bethesda, MD.
Stanford University · USAmsterdam UMC Location VUmc · NLCornell University · USNational Institutes of Health · USQueen Elizabeth Hospital · CNSt James's University Hospital · GBUniversity of California, Los Angeles · US

Funding

Hematopathology DiagnosisZIABC011070 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JAFFE, ELAINE · 2009 to 2025
$14.5M
6 · The paper itself

Abstract

objectivesThe 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology aimed to review B-cell proliferations of varied malignant potential associated with immunodeficiency.

methodsThe Workshop Panel reviewed all cases of B-cell hyperplasias, polymorphic B-lymphoproliferative disorders, Epstein-Barr virus (EBV)-positive mucocutaneous ulcer, and large B-cell proliferations associated with chronic inflammation and rendered consensus diagnoses. Disease definitions, boundaries with more aggressive B-cell proliferations, and association with EBV were explored.

resultsB-cell proliferations of varied malignant potential occurred in all immunodeficiency backgrounds. Presentation early in the course of immunodeficiency and in younger age groups and regression with reduction of immunosuppression were characteristic features. EBV positivity was essential for diagnosis in some hyperplasias where other specific defining features were absent.

conclusionsThis spectrum of B-cell proliferations show similarities across immunodeficiency backgrounds. Localized forms of immunodeficiency disorders arise in immunocompetent patients most likely due to chronic immune stimulation and, despite aggressive histologic features, often show indolent clinical behavior.

Indexed as

AdultAgedB-LymphocytesChildChild, PreschoolEducationEpstein-Barr Virus InfectionsFemaleHumansLymphoproliferative DisordersMaleMiddle AgedYoung AdultAutoimmuneEarly lesionEBVHIVIatrogenicNondestructive lesionPolymorphic lymphoproliferative disorderPosttransplant lymphoproliferative disorder

Identifiers

PMID28395107
PMCPMC6248636
OpenAlexW2613123314

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.