ArticlePloS one2017
Identification of a rice metal tolerance protein OsMTP11 as a manganese transporter.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 88 citations in OpenAlex.
- Molecular insights into cadmium transport and micronutrient crosstalk in rice: Towards minimizing grain Cd.Journal of integrative plant biology · 2026Review
- Overexpression and silencing of the cottonFrontiers in plant science · 2026Article
- AhMTP9-Mediated manganese tolerance mechanisms in peanut: integrated physiological and molecular responses of roots and leaves to Mn stress.BMC plant biology · 2025Article
- Review
- Article
- Genome-wide identification, expression and function analysis of theFrontiers in plant science · 2024Article
- Genetic adaptations of sea anemone to hydrothermal environment.Science advances · 2023Article
- Genome-Wide Identification and Expression Analysis of MTP (Metal Ion Transport Proteins) Genes in the Common Bean.Plants (Basel, Switzerland) · 2023Article
- Epigenetic Control of Plant Response to Heavy Metals.Plants (Basel, Switzerland) · 2023Review
- Transcriptome Sequencing Analysis of Root in Soybean Responding to Mn Poisoning.International journal of molecular sciences · 2023Article
- Comparative Transcriptome Analysis Reveals Complex Physiological Response and Gene Regulation in Peanut Roots and Leaves under Manganese Toxicity Stress.International journal of molecular sciences · 2023Article
- A Golgi-Located Transmembrane Nine Protein Gene TMN11 Functions in Manganese/Cadmium Homeostasis and Regulates Growth and Seed Development in Rice.International journal of molecular sciences · 2022Article
- Application of CRISPR/Cas system in cereal improvement for biotic and abiotic stress tolerance.Planta · 2022Review
- Natural Molecular Mechanisms of Plant Hyperaccumulation and Hypertolerance towards Heavy Metals.International journal of molecular sciences · 2022Review
- The Role of Sulfur in Agronomic Biofortification with Essential Micronutrients.Plants (Basel, Switzerland) · 2022Review
- Identification and functional analysis of cation-efflux transporter 1 from Brassica juncea L.BMC plant biology · 2022Article
- Identification and evolutionary analysis of the metal-tolerance protein family in eight Cucurbitaceae species.The plant genome · 2022Article
- The Rice Cation/HInternational journal of molecular sciences · 2021Article
- Genome-Wide Identification, Structure Characterization, Expression Pattern Profiling, and Substrate Specificity of the Metal Tolerance Protein Family inPlants (Basel, Switzerland) · 2021Article
- High-resolution genome-wide association study pinpoints metal transporter and chelator genes involved in the genetic control of element levels in maize grain.G3 (Bethesda, Md.) · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metal tolerance proteins (MTPs) are a gene family of cation efflux transporters that occur widely in plants and might serve an essential role in metal homeostasis and tolerance. Our research describes the identification, characterization, and localization of OsMTP11, a member of the MTP family from rice. OsMTP11 was expressed constitutively and universally in different tissues in rice plant. Heterologous expression in yeast showed that OsMTP11 complemented the hypersensitivity of mutant strains to Mn, and also complemented yeast mutants to other metals, including Co and Ni. Real time RT-PCR analysis demonstrated OsMTP11 expression was substantially enhanced following 4 h under Cd, Zn, Ni, and Mn treatments, suggesting possible roles of OsMTP11 involvement in heavy metal stress responses. Promoter analysis by transgenic assays with GUS as a reporter gene and mRNA in situ hybridization experiments showed that OsMTP11 was expressed specifically in conducting tissues in rice. DNA methylation assays of genomic DNA in rice treated with Cd, Zn, Ni, and Mn revealed that decreased DNA methylation levels were present in the OsMTP11 promoter region, which was consistent with OsMTP11 induced-expression patterns resulting from heavy metal stress. This result suggested that DNA methylation is one of major factors regulating expression of OsMTP11 through epigenetic mechanisms. OsMTP11 fused to green fluorescent protein (GFP) localized to the entire onion epidermal cell cytoplasm, while vacuolar membrane exhibited increased GFP signals, consistent with an OsMTP11 function in cation sequestration. Our results indicated that OsMTP11 might play vital roles in Mn and other heavy metal transportation in rice.
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