ArticleThe Journal of clinical psychiatry2017
Adverse Childhood Experiences and Risk for First-Episode Major Depression During the Menopause Transition.
Article in The Journal of clinical psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Menopause and the prison: A Systematic review exploring the experiences and support needs of women in prison in relation to the menopause.Women's health (London, England)Pooled it
- Impact of Tryptophan Depletion on Executive System Function during Menopause is Moderated by Childhood Adversity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Impact of early life adversity and tryptophan depletion on functional connectivity in menopausal women: A double-blind, placebo-controlled crossover study.Psychoneuroendocrinology · 2017Trial
- Associations Between Different Subtypes of Adverse Childhood Experiences with Reproductive Mood Disorders-a Scoping Review.Current psychiatry reports · 2026Article
- Advancing women's mental health: Recommendations from a National Academies of Sciences, Engineering, and Medicine workshop.PNAS nexus · 2026Article
- The Role of Adverse Childhood Experiences in the Development of Major Depressive Disorder and Treatment-Resistant Depression.Child psychiatry and human development · 2026Review
- Lifestyle medicine pillars for women's heart health.American journal of preventive cardiology · 2025Article
- A systematic review on the bidirectional relationship between trauma-related psychopathology and reproductive aging.Journal of mood and anxiety disorders · 2024Article
- Early Life Trauma, Emotion Dysregulation and Hormonal Sensitivity Across Female Reproductive Life Events.Current psychiatry reports · 2024Review
- Investing in family-centered early childhood education: A conceptual model for preventing firearm homicide among Black male youth in the United States.Preventive medicine · 2024Review
- Depressed, stressed, and inflamed: C-reactive protein linked with depression symptoms in midlife women with both childhood and current life stress.Stress and health : journal of the International Society for the Investigation of Stress · 2024Article
- The link between childhood traumatic events and the continuum of premenstrual disorders.Frontiers in psychiatry · 2024Article
- Polyvictimization and Adolescent Health and Well-Being in Ethiopia: The Mediating Role of Resilience.International journal of environmental research and public health · 2023Article
- Maternal adverse childhood experiences impact fetal adrenal volume in a sex-specific manner.Biology of sex differences · 2023Article
- Adverse childhood experiences and hormonal contraception: Interactive impact on sexual reward function.PloS one · 2023Article
- Enduring impact of childhood adversity: Affective modulation of acoustic startle response during pregnancy and postpartum.Physiology & behavior · 2023Article
- Childhood adversity predicts stronger premenstrual mood worsening, stress appraisal and cortisol decrease in women with Premenstrual Dysphoric Disorder.Frontiers in endocrinology · 2023Article
- The role of the hypothalamic-pituitary-adrenal axis in depression across the female reproductive lifecycle: current knowledge and future directions.Frontiers in endocrinology · 2023Review
- Does childhood maltreatment or current stress contribute to increased risk for major depression during the menopause transition?Psychological medicine · 2022Article
- Discontinuation of hormonal contraception due to changes in mood and decreases in sexual desire: the role of adverse childhood experiences.The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveStress exposures may have a differential impact on risk and resilience for depression depending on their timing across development. We sought to determine whether adverse childhood experiences (ACEs) and their onset with respect to puberty contribute to the increased risk observed in first-episode major depressive disorder (MDD) during the menopause transition.
methodsParticipants were from the Penn Ovarian Aging Study cohort, which is composed of women from Philadelphia County, Pennsylvania, who underwent behavioral, cognitive, and endocrine evaluations approximately yearly from 1996 to 2012 and completed the Adverse Childhood Experiences Questionnaire at study end point (n = 243). ACEs that first occurred 2 or more years before menarche were considered prepubertal. Incident menopause MDD was defined as first observed onset of the disorder in the perimenopause to postmenopause transition using the Structured Clinical Interview for DSM-III-R and the Primary Care Evaluation of Mental Disorders.
resultsIncident menopause MDD occurred in 48% of the 100 women who reported lifetime MDD. Women reporting ≥ 2 total ACEs were at significantly greater risk for lifetime MDD (adjusted odds ratio [aOR] = 2.05, P = .034) and incident menopause MDD (aOR = 2.58, P = .03) compared to those reporting 0 ACEs; women with ≥ 2 postpubertal ACEs were 2.3 times more likely to experience incidence menopause MDD (P = .024) after controlling for race, smoking, body mass index, and employment. Experiencing only 1 ACE in the prepubertal window, regardless of additional ACEs in postpuberty, was associated with reduced risk for lifetime and incident menopause MDD.
conclusionsTiming and number of adverse experiences with respect to puberty differentially impacted risk and resilience for MDD across the female life span and during the menopause transition in this community cohort.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.