Trial reportNutrition & diabetes2017
Effects of walnut oil on lipid profiles in hyperlipidemic type 2 diabetic patients: a randomized, double-blind, placebo-controlled trial.
Trial report in Nutrition & diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Does Walnut Supplementation Have Favourable Effect Apolipoprotein A, B and Blood Pressure? A Systematic Review, Meta-Analysis and Meta-Evidence of Randomised Clinical Trials.Endocrinology, diabetes & metabolism · 2026Pooled it
- Tree Nut and Peanut Consumption and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- The Effect of Walnut Intake on Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Nutrients · 2022Pooled it
- Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2022Pooled it
- One-year dietary supplementation with walnuts modifies exosomal miRNA in elderly subjects.European journal of nutrition · 2021Trial
- Trial
- Walnuts change lipoprotein composition suppressing TNFα-stimulated cytokine production by diabetic adipocyte.The Journal of nutritional biochemistry · 2019Trial
- Comparison of the effect of omega-3 supplements and fresh fish on lipid profile: a randomized, open-labeled trial.Nutrition & diabetes · 2017Trial
- Physicochemical Properties, Bioactive Components and Volatile Compounds of Dietary Fatty Acid Balanced Blend Oil.Foods (Basel, Switzerland) · 2026Article
- Molecular mechanisms driving the success of grafting impacted by walnut rootstock.BMC genomics · 2026Article
- Effects of Walnut Consumption on Blood Lipid Profile and Apolipoproteins in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-Analysis of 49 Randomized Controlled Trials.Food science & nutrition · 2026Review
- Characterizing the Phenolic Compounds in Iron Walnut Oil (Foods (Basel, Switzerland) · 2025Article
- African walnut (Frontiers in nutrition · 2025Article
- Nutritional Advantages of Walnut (Food science & nutrition · 2025Review
- The effect of health belief education on metabolic indices of patients with diabetes type II living in rural areas.Journal of education and health promotion · 2025Article
- Transcriptome analysis of lipid biosynthesis during kernel development in two walnut (Juglans regia L.) varieties of 'Xilin 3' and 'Xiangling'.BMC plant biology · 2024Article
- Chemical Characterization and Beneficial Effects of Walnut Oil on aMolecules (Basel, Switzerland) · 2024Article
- Can daily consumption of enriched fatty acids diet be effective in improving metabolic syndrome? An attractive paradox for walnut kernel.Food science & nutrition · 2024Review
- African walnut (Frontiers in nutrition · 2024Article
- Metabolomics and Transcriptomics Analyses Reveals the Molecular Regulatory Mechanisms of Walnut (International journal of molecular sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of herbal medicine is now well documented in preventing and controlling diabetes mellitus. The main aim of this study was to evaluate the effects of walnut oil consumption on lipid profiles of hyperlipidemic patients with type 2 diabetes.
methodsIn a randomized, double-blind, placebo-controlled clinical trial, 100 hyperlipidemic type 2 diabetic patients aged 35-75 years were assigned to receive 15 cc Persian walnut oil or placebo every day for 90 days. The primary outcomes were the lipid profiles.
resultsConsumption of walnut oil by type 2 hyperlipidemic diabetic patients resulted in a significant decrease in total cholesterol levels (treatment difference (TD)=-30.04, P<0.001), triglyceride (TG) level (TD=-15.04, P=0.021), low-density lipoprotein (LDL) level (TD=-30.44, P<0.001) and total cholesterol to high-density lipoprotein (HDL) ratio (TD=-0.72, P<0.001) compared to the control group. There was a trend toward increasing HDL level with consumption of walnut oil (TD=2.28, P=0.06). Frequency of patients reaching a LDL level below 100 was higher in the case group (20 vs 0%).
conclusionsAddition of walnut oil in the daily diet of type 2 diabetic patients improves lipid profiles. Thus, it may be associated with a coronary artery disease risk factor modulation. Also, walnut oil may serve as a helpful natural remedy for hyperlipidemic patients with type 2 diabetes.
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