Evidence map›Paper›PMID 28394346›Full record

ArticleOncogene2017

Post-translational modification of HINT1 mediates activation of MITF transcriptional activity in human melanoma cells.

A Motzik, E Amir, T Erlich, J Wang, B-G Kim, J M Han, J H Kim, H Nechushtan, M Guo, E Razin and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Re-evaluation of Diadenosine Tetraphosphate (ApFrontiers in molecular biosciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

A MotzikDepartment of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
E AmirDepartment of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
T ErlichDepartment of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
J WangState Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
B-G KimMedicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul, South Korea.
J M HanDepartment of Integrated OMICS for Biomedical Science, Yonsei University, Seoul, South Korea.
J H KimCollege of Pharmacy, Yonsei University, Seoul, South Korea.
H NechushtanOncology Department, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
M GuoDepartment of Cancer Biology, The Scripps Research Institute, Jupiter, FL, USA.
E RazinDepartment of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
S TshoriDepartment of Nuclear Medicine, Kaplan Medical Center, Rehovot, Israel.
Seoul National University · KRHadassah Medical Center · ILKaplan Medical Center · ILScripps Research Institute · USShanghai Institute of Organic Chemistry · CNYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microphthalmia transcription factor (MITF) is a basic helix-loop-helix leucine zipper (bHLH-Zip) DNA-binding protein. This transcription factor plays a crucial role in the physiological and pathological functions of distinct cell types. MITF transcriptional activity is inhibited by the histidine triad nucleotide-binding protein 1 (HINT1) through direct binding. We previously reported that this association is disrupted by the binding of the second messenger Ap

Indexed as

Protein Processing, Post-TranslationalTranscriptional ActivationAcetylationAdaptor Proteins, Signal TransducingCarrier ProteinsCell Line, TumorCyclin-Dependent Kinase 2DNA-Binding ProteinsDNA Mutational AnalysisHumansMast CellsMelanomaMembrane ProteinsMicrophthalmia-Associated Transcription FactorNerve Tissue ProteinsPhosphorylationAdaptor Proteins, Signal TransducingAP4A binding protein, humanCarrier ProteinsCDK2 protein, humanCyclin-Dependent Kinase 2DNA-Binding ProteinsHINT1 protein, humanMembrane ProteinsMicrophthalmia-Associated Transcription FactorMITF protein, humanNerve Tissue ProteinsTYROBP protein, human

Identifiers

PMID28394346
OpenAlexW2607449297

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.