Evidence map›Paper›PMID 28394331›Full record

ArticleNature medicine2017

Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance.

Donnele Daley, Vishnu R Mani, Navyatha Mohan, Neha Akkad, Atsuo Ochi, Daniel W Heindel, Ki Buom Lee, Constantinos P Zambirinis, Gautam Sd Balasubramania Pandian, Shivraj Savadkar and 14 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 237 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
237citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

237 citing papers in PubMed, 1 synthesis or guideline pooled it, 372 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
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  7. Review
  8. Review
  9. Review
  10. Synthetic Ligands of Myeloid C-Type Lectin Receptors.Chembiochem : a European journal of chemical biology · 2026
    Review
  11. Article
  12. Article
  13. Review
  14. Apoptotic markers and Dectin-1BMC cardiovascular disorders · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. T cell-intrinsic PRR signaling in immunity and pathology.Acta biochimica et biophysica Sinica · 2026
    Review
  19. Review
  20. Review

177 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 1 institution in 1 country.

Donnele DaleyS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.
Vishnu R ManiS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.
Navyatha MohanS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.
Neha AkkadS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.
Atsuo OchiS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.
Daniel W HeindelDepartment of Chemistry, New York University, New York, New York, USA.
Ki Buom LeeS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.
Constantinos P ZambirinisS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.ORCID http://orcid.org/0000-0003-2740-3259
Gautam Sd Balasubramania PandianS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.
Shivraj SavadkarS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.
Alejandro Torres-HernandezS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.
Shruti NayakDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA.
Ding WangDepartment of Medicine, New York University School of Medicine, New York, New York, USA.
Mautin HundeyinS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.
Brian DiskinS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.
Berk AykutS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.
Gregor WerbaS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.
Rocky M BarillaS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.ORCID http://orcid.org/0000-0002-8062-7246
Robert RodriguezS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.
Steven ChangS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.
Lawrence GardnerDepartment of Medicine, New York University School of Medicine, New York, New York, USA.
Lara K MahalDepartment of Chemistry, New York University, New York, New York, USA.
Beatrix UeberheideDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA.
George MillerS.A. Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York, USA.
New York University · US

Funding

Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5M
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
Institutional Clinical and Translational Science AwardUL1TR000038 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CRONSTEIN, BRUCE NEIL · 2012 to 2014
$16.8M
Research Training for Physician-Scientists in Gastrointestinal OncologyT32CA193111 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BAR-SAGI, DAFNA, WOLFGANG, CHRISTOPHER L. · 2015 to 2024
$2.7M
Toll-like Receptor Regulation of Pancreatic TumorigenesisR01CA168611 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COHEN, DEIRDRE, MILLER, GEORGE · 2013 to 2019
$2.1M
Regulation of Pancreatic Oncogenesis by the Gut MicrobiomeR01CA206105 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SAXENA, DEEPAK, SIMEONE, DIANE M · 2017 to 2021
$1.9M
Role of Dendritic Cell Activation in the Pathogenesis of Liver FibrosisK08DK085278 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MILLER, GEORGE · 2010 to 2014
$916k
The Role of Dendritic Cells in Pancreatic TumorigenesisR21CA155649 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MILLER, GEORGE · 2011 to 2012
$404k
NCATS NIH HHS UL1 TR000038NCATS NIH HHS UL1 TR001445NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA168611NCI NIH HHS R01 CA206105NCI NIH HHS R21 CA155649NCI NIH HHS T32 CA193111NIDDK NIH HHS K08 DK085278
6 · The paper itself

Abstract

The progression of pancreatic oncogenesis requires immune-suppressive inflammation in cooperation with oncogenic mutations. However, the drivers of intratumoral immune tolerance are uncertain. Dectin 1 is an innate immune receptor crucial for anti-fungal immunity, but its role in sterile inflammation and oncogenesis has not been well defined. Furthermore, non-pathogen-derived ligands for dectin 1 have not been characterized. We found that dectin 1 is highly expressed on macrophages in pancreatic ductal adenocarcinoma (PDA). Dectin 1 ligation accelerated the progression of PDA in mice, whereas deletion of Clec7a-the gene encoding dectin 1-or blockade of dectin 1 downstream signaling was protective. We found that dectin 1 can ligate the lectin galectin 9 in mouse and human PDA, which results in tolerogenic macrophage programming and adaptive immune suppression. Upon disruption of the dectin 1-galectin 9 axis, CD4

Indexed as

AnimalsBlotting, WesternCarcinogenesisCarcinoma, Pancreatic DuctalDectin-1Epithelial CellsFlow CytometryGalectinsGene Knockdown TechniquesHumansImmune ToleranceImmunohistochemistryImmunoprecipitationLectins, C-TypeMass SpectrometryMiceDectin-1galectin 9, mouseGalectinsLectins, C-TypeLGALS9 protein, humanSyk Kinase

Identifiers

PMID28394331
PMCPMC5419876
OpenAlexW2605540758

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.