Evidence map›Paper›PMID 28394295›Full record

ReviewPlants (Basel, Switzerland)2017

Antimicrobial Resistance and the Alternative Resources with Special Emphasis on Plant-Based Antimicrobials-A Review.

Harish Chandra, Parul Bishnoi, Archana Yadav, Babita Patni, Abhay Prakash Mishra, Anant Ram Nautiyal

Open access · goldAbstract readReview
In one paragraph

Review in Plants (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 1 pooled it
39.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 1 synthesis or guideline pooled it, 376 citations in OpenAlex.

  1. Pooled it
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  13. Timbe (Pharmaceuticals (Basel, Switzerland) · 2025
    Article
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  20. Eco-friendly Synthesis ofPharmaceutical nanotechnology · 2025
    Review

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Harish ChandraHigh Altitude Plant Physiology Research Centre, Hemvati Nandan Bahuguna (H.N.B.) Garhwal University, Srinagar, Garhwal 246174, Uttarakhand, India. hreesh5@gmail.com.
Parul BishnoiDepartment of Microbiology, Bangalore City College, Bangalore 560043, India. bishnoiparul@gmail.com.
Archana YadavDepartment of Microbiology, Institute of Biosciences and Biotechnology, Chhatrapati Shahu Ji Maharaj (C.S.J.M.) University, Kanpur 208024, India. archana25578@gmail.com.
Babita PatniHigh Altitude Plant Physiology Research Centre, Hemvati Nandan Bahuguna (H.N.B.) Garhwal University, Srinagar, Garhwal 246174, Uttarakhand, India. babita28paatni@gmail.com.
Abhay Prakash MishraDepartment of Pharmaceutical Chemistry, Hemvati Nandan Bahuguna (H.N.B.) Garhwal University, Srinagar, Garhwal 246174, Uttarakhand, India. abhaycimap@gmail.com.
Anant Ram NautiyalHigh Altitude Plant Physiology Research Centre, Hemvati Nandan Bahuguna (H.N.B.) Garhwal University, Srinagar, Garhwal 246174, Uttarakhand, India. arnautiyal@gmail.com.
Hemwati Nandan Bahuguna Garhwal University · INBangalore University · INChhatrapati Shahu Ji Maharaj University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Indiscriminate and irrational use of antibiotics has created an unprecedented challenge for human civilization due to microbe's development of antimicrobial resistance. It is difficult to treat bacterial infection due to bacteria's ability to develop resistance against antimicrobial agents. Antimicrobial agents are categorized according to their mechanism of action, i.e., interference with cell wall synthesis, DNA and RNA synthesis, lysis of the bacterial membrane, inhibition of protein synthesis, inhibition of metabolic pathways, etc. Bacteria may become resistant by antibiotic inactivation, target modification, efflux pump and plasmidic efflux. Currently, the clinically available treatment is not effective against the antibiotic resistance developed by some bacterial species. However, plant-based antimicrobials have immense potential to combat bacterial, fungal, protozoal and viral diseases without any known side effects. Such plant metabolites include quinines, alkaloids, lectins, polypeptides, flavones, flavonoids, flavonols, coumarin, terpenoids, essential oils and tannins. The present review focuses on antibiotic resistance, the resistance mechanism in bacteria against antibiotics and the role of plant-active secondary metabolites against microorganisms, which might be useful as an alternative and effective strategy to break the resistance among microbes.

Indexed as

antibiotic resistanceantimicrobialmechanism of actionplant metabolite

Identifiers

PMID28394295
PMCPMC5489788
OpenAlexW2606416324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.