Evidence map›Paper›PMID 28394292›Full record

ArticleInternational journal of environmental research and public health2017

Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand.

Muneko Nishijo, Kowit Nambunmee, Dhitiwass Suvagandha, Witaya Swaddiwudhipong, Werawan Ruangyuttikarn, Yoshikazu Nishino

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Muneko NishijoDepartment of Public Health, Kanazawa Medical University Hospital, Uchinada 920-0293, Japan. ni-koei@kanazawa-med.ac.jp.
Kowit NambunmeeSchool of Health Science, Mae Fah Luang University, Chiang Rai 57100, Thailand. kowit.nam@mfu.ac.th.
Dhitiwass SuvagandhaEnvironmental Science Program, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand. dhitiwass@gmail.com.
Witaya SwaddiwudhipongMae Sot General Hospital, Mae Sot District, Tak Province 63110, Thailand. swaddi@hotmail.com.
Werawan RuangyuttikarnDepartment of Forensic Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. ruangyuttikarn@gmail.com.
Yoshikazu NishinoDepartment of Public Health, Kanazawa Medical University Hospital, Uchinada 920-0293, Japan. ynishino@kanazawa-med.ac.jp.
Chiang Mai University · THKanazawa Medical University · JPKanazawa Medical University Hospital · JPMae Fah Luang University · THMaesot General Hospital · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To elucidate the influence of cadmium exposure on bone metabolism, associations between urinary/blood cadmium and bone resorption/formation markers were investigated in older cadmium exposed men and women. Increased urinary cross-linked N-telopeptide of type I collagen (NTx), a bone resorption marker, was found to be associated with increased levels of parathyroid hormone, fractional excretion of calcium, and urinary/blood cadmium after adjusting for confounding factors in men. In women, urinary NTx was significantly associated with only urinary cadmium and a strong relationship with increased fractional excretion of calcium. Risk for bone metabolic disorders, indicated by high urinary NTx, significantly increased in men with blood cadmium ≥ 10 μg/L or urinary cadmium ≥ 10 μg/g creatinine. Increased osteocalcin level was significantly associated with increased blood cadmium in men. In conclusion, cadmium exposure appeared to have an influence on bone remodeling both bone resorption and formation in this population of older Thai men, and blood cadmium was more closely associated with bone metabolism than urinary cadmium.

Indexed as

AdultBiomarkersBone ResorptionCadmiumCalciumCollagen Type ICreatinineEnvironmental PollutantsEnvironmental PollutionFemaleHumansMaleOsteoporosisParathyroid HormoneSex CharacteristicsThailandBiomarkersCadmiumCalciumCollagen Type ICreatinineEnvironmental PollutantsParathyroid Hormoneblood cadmiumbone formation markerbone resorption markerThailandurinary cadmiumvitamin D binding proteinwhole parathyroid hormone

Identifiers

PMID28394292
PMCPMC5409602
OpenAlexW2607092113

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.