ArticleMolecules (Basel, Switzerland)2017
Anti-Inflammatory and Antioxidant Properties of Casein Hydrolysate Produced Using High Hydrostatic Pressure Combined with Proteolytic Enzymes.
Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 112 citations in OpenAlex.
- Casein Hydrolysate Peptides Attenuate Immunosenescence and Inflammaging in a D-Galactose-Induced Mouse Model of Aging.Biology · 2026Article
- Casein genotypes associate with baseline and dynamic regression components of seminal quality in Murciano-Granadina bucks.Scientific reports · 2026Article
- Anti-Inflammatory Activity ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Antimicrobial and Anti-Inflammatory Bioactive Peptides: Their Role in Potential Therapeutic Applications for Periodontitis-A Narrative Review.Nutrients · 2025Review
- Novel Hybrid Peptide DEFB126 (1-39)-TP5 Inhibits LPS-Induced Inflammatory Responses and Oxidative Stress by Neutralizing LPS and Blocking the TLR4/MD2-NFκB Signaling Axis.Antioxidants (Basel, Switzerland) · 2025Article
- Effect of β-casein A2 cow milk supplementation on physical growth, inflammation, growth-related hormones, and nutritional biomarkers in stunted children.Annals of pediatric endocrinology & metabolism · 2025Article
- Peptides From Animal and Fishery Byproducts: Uplifting the Functionality of Fifth Quarter.Food science & nutrition · 2025Review
- Synergistic effect between polishing and high-pressure enzyme treatment for low protein rice production.Food science and biotechnology · 2025Article
- Protein Hydrolysates from Fishery Processing By-Products: Production, Characteristics, Food Applications, and Challenges.Foods (Basel, Switzerland) · 2023Review
- From microbes to molecules: a review of microbial-driven antioxidant peptide generation.World journal of microbiology & biotechnology · 2023Review
- An Overview of the Occurrence of Bioactive Peptides in Different Types of Cheeses.Foods (Basel, Switzerland) · 2023Review
- Article
- Preventative and therapeutic potential of animal milk components against COVID-19: A comprehensive review.Food science & nutrition · 2023Article
- Production of Food-Derived Bioactive Peptides with Potential Application in the Management of Diabetes and Obesity: A Review.Journal of agricultural and food chemistry · 2023Review
- Transepithelial transport and cellular mechanisms of food-derived antioxidant peptides.Heliyon · 2022Review
- Hydrolysis of Soybean Milk Protein by Papain: Antioxidant, Anti-Angiotensin, Antigenic and Digestibility Perspectives.Bioengineering (Basel, Switzerland) · 2022Article
- Review
- Antioxidant and Antimicrobial Peptides Derived from Food Proteins.Molecules (Basel, Switzerland) · 2022Review
- Production, Purification, and Potential Health Applications of Edible Seeds' Bioactive Peptides: A Concise Review.Foods (Basel, Switzerland) · 2021Review
- A Response Surface Methodology (RSM) Approach for Optimizing the Attenuation of Human IgE-Reactivity to β-Lactoglobulin (β-Lg) by Hydrostatic High Pressure Processing.Foods (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Casein-derived peptides are shown to possess radical scavenging and metal chelating properties. The objective of this study was to evaluate novel anti-inflammatory properties of casein hydrolysates (CH) produced by an eco-friendly process that combines high hydrostatic pressure with enzymatic hydrolysis (HHP-EH). Casein was hydrolysed by different proteases, including flavourzyme (Fla), savinase (Sav), thermolysin (Ther), trypsin (Try), and elastase (Ela) at 0.1, 50, 100, and 200 MPa pressure levels under various enzyme-to-substrate ratios and incubation times. Casein hydrolysates were evaluated for the degree of hydrolysis (DH), molecular weight distribution patterns, and anti-inflammatory properties in chemical and cellular models. Hydrolysates produced using HHP-EH exhibited higher DH values and proportions of smaller peptides compared to atmospheric pressure-enzymatic hydrolysis (AP-EH). Among five enzymes, Fla-digested HHP-EH-CH (HHP-Fla-CH) showed significantly higher antioxidant properties than AP-Fla-CH. The anti-inflammatory properties of HHP-Fla-CH were also observed by significantly reduced nitric oxide and by the suppression of the synthesis of pro-inflammatory cytokines in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. Liquid chromatography with tandem mass spectrometry (LC-MS/MS) revealed that 59% of the amino acids of the peptides in HHP-Fla-CH were composed of proline, valine, and leucine, indicating the potential anti-inflammatory properties. In conclusion, the HHP-EH method provides a promising technology to produce bioactive peptides from casein in an eco-friendly process.
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Registered trials
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