ArticleJournal of neurotrauma2017
A Three-Dimensional Computational Human Head Model That Captures Live Human Brain Dynamics.
Article in Journal of neurotrauma, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Quantifying Morphology-Related Deviations in Brain Strain Using an Automated Mesh Morphing Method.Annals of biomedical engineering · 2026Article
- The effect of microstructural variations in tendon and ligament on diffusion tensor MRI.bioRxiv : the preprint server for biology · 2026Article
- In silico investigation of brain tissue responses associated with mild blast traumatic brain injury.Frontiers in bioengineering and biotechnology · 2026Article
- Multimodal characterization of intracranial biomechanics in a 3D biofidelic head surrogate.Journal of the mechanical behavior of biomedical materials · 2026Article
- Measurement of Residual Stress in the Brain.Journal of biomechanical engineering · 2025Article
- Full-field, frequency-domain comparison of simulated and measured human brain deformation.Biomechanics and modeling in mechanobiology · 2025Article
- Effect of Direction and Frequency of Skull Motion on Mechanical Vulnerability of the Human Brain.Journal of biomechanical engineering · 2023Article
- Use of Brain Biomechanical Models for Monitoring Impact Exposure in Contact Sports.Annals of biomedical engineering · 2022Review
- Revealing the Effect of Skull Deformation on Intracranial Pressure Variation During the Direct Interaction Between Blast Wave and Surrogate Head.Annals of biomedical engineering · 2022Article
- Data-driven Uncertainty Quantification in Computational Human Head Models.Computer methods in applied mechanics and engineering · 2022Article
- Effective Viscoplastic-Softening Model Suitable for Brain Impact Modelling.Materials (Basel, Switzerland) · 2022Article
- Oblique impact responses of Hybrid III and a new headform with more biofidelic coefficient of friction and moments of inertia.Frontiers in bioengineering and biotechnology · 2022Article
- MR Imaging of Human Brain Mechanics In Vivo: New Measurements to Facilitate the Development of Computational Models of Brain Injury.Annals of biomedical engineering · 2021Review
- The relation between neck strength and psychological distress: preliminary evidence from collegiate soccer athletes.Concussion (London, England) · 2021Article
- Prospective study of the association between sport-related concussion and brain morphometry (3T-MRI) in collegiate athletes: study from the NCAA-DoD CARE Consortium.British journal of sports medicine · 2021Article
- Multi-Scale White Matter Tract Embedded Brain Finite Element Model Predicts the Location of Traumatic Diffuse Axonal Injury.Journal of neurotrauma · 2021Article
- Integrating material properties from magnetic resonance elastography into subject-specific computational models for the human brain.Brain multiphysics · 2021Article
- In vivo estimates of axonal stretch and 3D brain deformation during mild head impact.Brain multiphysics · 2020Article
- Transcranial focused ultrasound generates skull-conducted shear waves: Computational model and implications for neuromodulation.Applied physics letters · 2020Article
- Embedded axonal fiber tracts improve finite element model predictions of traumatic brain injury.Biomechanics and modeling in mechanobiology · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Diffuse axonal injury (DAI) is a debilitating consequence of traumatic brain injury (TBI) attributed to abnormal stretching of axons caused by blunt head trauma or acceleration of the head. We developed an anatomically accurate, subject-specific, three-dimensional (3D) computational model of the human brain, and used it to study the dynamic deformations in the substructures of the brain when the head is subjected to rotational accelerations. The computational head models use anatomy and morphology of the white matter fibers obtained using MRI. Subject-specific full-field shearing motions in live human brains obtained through a recently developed tagged MRI imaging technique are then used to validate the models by comparing the measured and predicted heterogeneous dynamic mechanical response of the brain. These results are used to elucidate the dynamics of local shearing deformations in the brain substructures caused by rotational acceleration of the head. Our work demonstrates that the rotational dynamics of the brain has a timescale of ∼100 ms as determined by the shearing wave speeds, and thus the injuries associated with rotational accelerations likely occur over these time scales. After subject-specific validation using the live human subject data, a representative subject-specific head model is used to simulate a real life scenario that resulted in a concussive injury. Results suggest that regions of the brain, in the form of a toroid, encompassing the white matter, the cortical gray matter, and outer parts of the limbic system have a higher susceptibility to injury under axial rotations of the head.
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