Evidence map›Paper›PMID 28394196›Full record

ArticleTissue engineering. Part A2017

Reactive Oxygen Species Shielding Hydrogel for the Delivery of Adherent and Nonadherent Therapeutic Cell Types<sup/>.

Bryan R Dollinger, Mukesh K Gupta, John R Martin, Craig L Duvall

Open access · greenAbstract read
In one paragraph

Article in Tissue engineering. Part A, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 50 citations in OpenAlex.

  1. Immunomodulatory Delivery Materials for Tissue Repair.Advanced healthcare materials · 2025
    Review
  2. Article
  3. Review
  4. Smart stimuli-responsive drug delivery systems in spotlight of COVID-19.Asian journal of pharmaceutical sciences · 2023
    Review
  5. Article
  6. Review
  7. Review
  8. Collagen- and hyaluronic acid-based hydrogels and their biomedical applications.Materials science & engineering. R, Reports : a review journal · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Microsphere antioxidant and sustained erythropoietin-R76E release functions cooperate to reduce traumatic optic neuropathy.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Article
  13. Article
  14. Bioresponsive drug delivery systems for the treatment of inflammatory diseases.Journal of controlled release : official journal of the Controlled Release Society · 2020
    Review
  15. Review
  16. Biomaterial-Based Metabolic Regulation in Regenerative Engineering.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019
    Review
  17. Systemic delivery of a Gli inhibitor via polymeric nanocarriers inhibits tumor-induced bone disease.Journal of controlled release : official journal of the Controlled Release Society · 2019
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bryan R DollingerDepartment of Biomedical Engineering, Vanderbilt University , Nashville, Tennessee.
Mukesh K GuptaDepartment of Biomedical Engineering, Vanderbilt University , Nashville, Tennessee.
John R MartinDepartment of Biomedical Engineering, Vanderbilt University , Nashville, Tennessee.
Craig L DuvallDepartment of Biomedical Engineering, Vanderbilt University , Nashville, Tennessee.
Vanderbilt University · US

Funding

Integrated Training in Engineering and DiabetesT32DK101003 · NIDDK · VANDERBILT UNIVERSITY · PI Jamey D. Young · 2014 to 2026
$3.9M
NIDDK NIH HHS T32 DK101003
6 · The paper itself

Abstract

Cell therapies suffer from poor survival post-transplant due to placement into hostile implant sites characterized by host immune response and innate production of high levels of reactive oxygen species (ROS). We hypothesized that cellular encapsulation within an injectable, antioxidant hydrogel would improve viability of cells exposed to high oxidative stress. To test this hypothesis, we applied a dual thermo- and ROS-responsive hydrogel comprising the ABC triblock polymer poly[(propylene sulfide)-block-(N,N-dimethyl acrylamide)-block-(N-isopropylacrylamide)] (PPS

Indexed as

Mesenchymal Stem Cell TransplantationAnimalsCell AdhesionCell CountCell DeathCytoprotectionHumansHydrogelsHydrogen PeroxideMesenchymal Stem CellsMicePolymersReactive Oxygen SpeciesRheologyHydrogelsHydrogen PeroxidePolymersReactive Oxygen Speciesantioxidantcell-deliveryhydrogelthermoresponsive

Identifiers

PMID28394196
PMCPMC5653132
OpenAlexW2592829642

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.