ArticleThe New phytologist2017
Quantitative analysis of the tomato nuclear proteome during Phytophthora capsici infection unveils regulators of immunity.
Article in The New phytologist, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
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- Differential Participation of Plant Ribosomal Proteins from the Small Ribosomal Subunit in Protein Translation under Stress.Biomolecules · 2023Article
- Uptake of oomycete RXLR effectors into host cells by clathrin-mediated endocytosis.The Plant cell · 2023Article
- Specific alterations in riboproteomes composition of isonicotinic acid treated arabidopsis seedlings.Plant molecular biology · 2023Article
- Comprehensive Genome-Wide Analysis and Expression Pattern Profiling ofPlants (Basel, Switzerland) · 2022Article
- Protein Phosphorylation Changes During Systemic Acquired Resistance inFrontiers in plant science · 2021Article
- LC-MS Based Draft Map of theFrontiers in plant science · 2021Article
- Developmentally regulated activation of defense allows for rapid inhibition of infection in age-related resistance to Phytophthora capsici in cucumber fruit.BMC genomics · 2020Article
- Nuclear proteome of virus-infected and healthy potato leaves.BMC plant biology · 2020Article
- Dissection of complex traits of tomato in the post-genome era.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Review
- At-Hook Motif Nuclear Localised Protein 18 as a Novel Modulator of Root System Architecture.International journal of molecular sciences · 2020Article
- High-Throughput Sequencing-Based Identification of Arabidopsis miRNAs Induced byFrontiers in microbiology · 2020Article
- Proteomics: a powerful tool to study plant responses to biotic stress.Plant methods · 2019Review
- Quantitative Proteomics of Potato Leaves Infected withInternational journal of molecular sciences · 2019Article
- Late ribosomal protein localization inFEBS open bio · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Plant-pathogen interactions are complex associations driven by the interplay of host and microbe-encoded factors. With secreted pathogen proteins (effectors) and immune signalling components found in the plant nucleus, this compartment is a battleground where susceptibility is specified. We hypothesized that, by defining changes in the nuclear proteome during infection, we can pinpoint vital components required for immunity or susceptibility. We tested this hypothesis by documenting dynamic changes in the tomato (Solanum lycopersicum) nuclear proteome during infection by the oomycete pathogen Phytophthora capsici. We enriched nuclei from infected and noninfected tissues and quantitatively assessed changes in the nuclear proteome. We then tested the role of candidate regulators in immunity through functional assays. We demonstrated that the host nuclear proteome dynamically changes during P. capsici infection. We observed that known nuclear immunity factors were differentially expressed and, based on this observation, selected a set of candidate regulators that we successfully implicated in immunity to P. capsici. Our work exemplifies a powerful strategy to gain rapid insight into important nuclear processes that underpin complex crop traits such as resistance. We have identified a large set of candidate nuclear factors that may underpin immunity to pathogens in crops.
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