ArticleScientific reports2017
Inhibition of melanogenesis by jineol from Scolopendra subspinipes mutilans via MAP-Kinase mediated MITF downregulation and the proteasomal degradation of tyrosinase.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 71 citations in OpenAlex.
- Anti-melanogenic and Antioxidant Activities of Lactiplantibacillus plantarum Strains in Skin Cells via the CREB/MITF and Nrf2/HO-1 Pathways.Probiotics and antimicrobial proteins · 2025Article
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- Silk Biowaste Protein Mediated Silver Nanoparticles Synthesis and Analysis of Anti-Inflammatory, Wound Healing, Antidiabetic, Antioxidant, Tyrosinase Inhibition, and Antibacterial Mechanism of Action.International journal of nanomedicine · 2025Article
- 10(E)-Pentadecenoic Acid Inhibits Melanogenesis Partly Through Suppressing the Intracellular MITF/Tyrosinase Axis.Antioxidants (Basel, Switzerland) · 2024Article
- Anti-Melanogenic Effects of Umbelliferone: In Vitro and Clinical Studies.Molecules (Basel, Switzerland) · 2024Article
- Thioquinoline derivatives conjugated to thiosemicarbazide as potent tyrosinase inhibitors with anti-melanogenesis properties.Scientific reports · 2023Article
- Antioxidant Potential-Rich Betel Leaves (Antioxidants (Basel, Switzerland) · 2023Article
- Protopanaxadiol-Enriched Rice Extracts Suppressed Oxidative and Melanogenic Activities in Melan-a Cells.Antioxidants (Basel, Switzerland) · 2023Article
- Maclurin Exhibits Antioxidant and Anti-Tyrosinase Activities, Suppressing Melanogenesis.Antioxidants (Basel, Switzerland) · 2022Article
- Fuzhuan Brick Tea Boosts Melanogenesis and Prevents Hair Graying through Reduction of Oxidative Stress viaAntioxidants (Basel, Switzerland) · 2022Article
- Enhanced Anti-Skin-Aging Activity of Yeast Extract-Treated Resveratrol Rice DJ526.Molecules (Basel, Switzerland) · 2022Article
- GIF-2209, an Oxindole Derivative, Accelerates Melanogenesis and Melanosome Secretion via the Modification of Lysosomes in B16F10 Mouse Melanoma Cells.Molecules (Basel, Switzerland) · 2021Article
- Pseudoalteromone A, a Ubiquinone Derivative from MarineMarine drugs · 2021Article
- Sargahydroquinoic Acid Suppresses Hyperpigmentation by cAMP and ERK1/2-Mediated Downregulation of MITF in α-MSH-Stimulated B16F10 Cells.Foods (Basel, Switzerland) · 2021Article
- Antioxidant and Anti-Melanogenic Activities of Heat-Treated Licorice (Wongam,Current issues in molecular biology · 2021Article
- Antioxidant and Antimelanogenic Activities of Kimchi-DerivedJournal of microbiology and biotechnology · 2021Article
- Antimelanogenesis Effects of Theasinensin A.International journal of molecular sciences · 2021Article
- Anti-Melanogenic Properties of Velutin and Its Analogs.Molecules (Basel, Switzerland) · 2021Article
- Catalysis-based specific detection and inhibition of tyrosinase and their application.Journal of pharmaceutical analysis · 2020Review
- Fermented Unpolished Black Rice (Journal of microbiology and biotechnology · 2020Article
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, the authors investigated the anti-melanogenic effects of 3,8-dihydroxyquinoline (jineol) isolated from Scolopendra subspinipes mutilans, the mechanisms responsible for its inhibition of melanogenesis in melan-a cells, and its antioxidant efficacy. Mushroom tyrosinase activities and melanin contents were determined in melan-a cells, and the protein and mRNA levels of MITF, tyrosinase, TYRP-1, and TYRP-2 were assessed. Jineol exhibited significant, concentration-dependent antioxidant effects as determined by DPPH, ABTS, CUPRAC, and FRAP assays. Jineol significantly inhibited mushroom tyrosinase activity by functioning as an uncompetitive inhibitor, and markedly inhibited melanin production and intracellular tyrosinase activity in melan-a cells. In addition, jineol abolished the expressions of tyrosinase, TYRP-1, TYRP-2, and MITF, thereby blocking melanin production and interfering with the phosphorylations of ERK1/2 and p38. Furthermore, specific inhibitors of ERK1/2 and p38 prevented melanogenesis inhibition by jineol, and the proteasome inhibitor (MG-132) prevented jineol-induced reductions in cellular tyrosinase levels. Taken together, jineol was found to stimulate MAP-kinase (ERK1/2 and p38) phosphorylation and the proteolytic degradation pathway, which led to the degradations of MITF and tyrosinase, and to suppress the productions of melanin.
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