ArticleScientific reports2017
Transcriptomic changes in an animal-bacterial symbiosis under modeled microgravity conditions.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Immune challenges and pathogen risks in edible insects: safeguarding health in space life-support systems.Frontiers in physiology · 2025Review
- Impact of modeled microgravity stress on innate immunity in a beneficial animal-microbe symbiosis.Scientific reports · 2024Article
- Modeled microgravity alters apoptotic gene expression and caspase activity in the squid-vibrio symbiosis.BMC microbiology · 2022Article
- Modeled microgravity alters lipopolysaccharide and outer membrane vesicle production of the beneficial symbiont Vibrio fischeri.NPJ microgravity · 2021Article
- A network approach to elucidate and prioritize microbial dark matter in microbial communities.The ISME journal · 2021Article
- Integrating the Ecosystem Services Framework to Define Dysbiosis of the Breastfed Infant Gut: The Role ofFrontiers in nutrition · 2020Article
- Spaceflight and simulated microgravity conditions increase virulence ofNPJ microgravity · 2020Article
- Molecular response of Deinococcus radiodurans to simulated microgravity explored by proteometabolomic approach.Scientific reports · 2019Article
- Persistent symbiont colonization leads to a maturation of hemocyte response in the Euprymna scolopes/Vibrio fischeri symbiosis.MicrobiologyOpen · 2019Article
- Critical symbiont signals drive both local and systemic changes in diel and developmental host gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Transcriptional profiling of the mutualistic bacteriumNPJ microgravity · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spaceflight imposes numerous adaptive challenges for terrestrial life. The reduction in gravity, or microgravity, represents a novel environment that can disrupt homeostasis of many physiological processes. Additionally, it is becoming increasingly clear that an organism's microbiome is critical for host health and examining its resiliency in microgravity represents a new frontier for space biology research. In this study, we examine the impact of microgravity on the interactions between the squid Euprymna scolopes and its beneficial symbiont Vibrio fischeri, which form a highly specific binary mutualism. First, animals inoculated with V. fischeri aboard the space shuttle showed effective colonization of the host light organ, the site of the symbiosis, during space flight. Second, RNA-Seq analysis of squid exposed to modeled microgravity conditions exhibited extensive differential gene expression in the presence and absence of the symbiotic partner. Transcriptomic analyses revealed in the absence of the symbiont during modeled microgravity there was an enrichment of genes and pathways associated with the innate immune and oxidative stress response. The results suggest that V. fischeri may help modulate the host stress responses under modeled microgravity. This study provides a window into the adaptive responses that the host animal and its symbiont use during modeled microgravity.
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