ArticleScientific reports2017
Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Odorant degrading enzyme candidates enriched in the antennae of the white-spotted flower chafer,Frontiers in insect science · 2026Article
- Phenethyl Acetate as an Agonist of Insect Odorant Receptor Co-Receptor (Orco): Molecular Mechanisms and Functional Insights.International journal of molecular sciences · 2025Article
- Identification and biophysical characterization of potential phytochemical inhibitors of carboxyl/choline esterase from Helicoverpa armigera for advancing integrated pest management strategies.Scientific reports · 2024Article
- Lipases and carboxylesterases affect moth sex pheromone compounds involved in interspecific mate recognition.Nature communications · 2023Article
- Review
- Genome-wide identification of candidate chemosensory receptors in the bean bugFrontiers in physiology · 2023Article
- Structure of an antennally-expressed carboxylesterase suggests lepidopteran odorant degrading enzymes are broadly tuned.Current research in insect science · 2023Article
- Genetic mechanisms modulating behaviour through plastic chemosensory responses in insects.Molecular ecology · 2023Review
- Olfactory coding in honeybees.Cell and tissue research · 2021Review
- An Overview of Antennal Esterases in Lepidoptera.Frontiers in physiology · 2021Review
- Molecular mechanisms of olfactory detection in insects: beyond receptors.Open biology · 2020Article
- The Drosophila odorant-binding protein 28a is involved in the detection of the floral odour ß-ionone.Cellular and molecular life sciences : CMLS · 2020Article
- Article
- Functional Analyses of House Fly Carboxylesterases Involved in Insecticide Resistance.Frontiers in physiology · 2020Article
- Genomics Analysis of L-DOPA Exposure inG3 (Bethesda, Md.) · 2019Article
- Identification and expression of candidate chemosensory receptors in the white-spotted flower chafer, Protaetia brevitarsis.Scientific reports · 2019Article
- Molecular evolution of juvenile hormone esterase-like proteins in a socially exchanged fluid.Scientific reports · 2018Article
- Evidence of peripheral olfactory impairment in the domestic silkworms: insight from the comparative transcriptome and population genetics.BMC genomics · 2018Article
- A subset of chemosensory genes differs between two populations of a specialized leaf beetle after host plant shift.Ecology and evolution · 2018Article
- Comparative transcriptome analysis of Apis mellifera antennae of workers performing different tasks.Molecular genetics and genomics : MGG · 2018Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous electrophysiological and behavioural studies implicate esterase 6 in the processing of the pheromone cis-vaccenyl acetate and various food odorants that affect aggregation and reproductive behaviours. Here we show esterase 6 has relatively high activity against many of the short-mid chain food esters, but negligible activity against cis-vaccenyl acetate. The crystal structure of esterase 6 confirms its substrate-binding site can accommodate many short-mid chain food esters but not cis-vaccenyl acetate. Immunohistochemical assays show esterase 6 is expressed in non-neuronal cells in the third antennal segment that could be accessory or epidermal cells surrounding numerous olfactory sensilla, including basiconics involved in food odorant detection. Esterase 6 is also produced in trichoid sensilla, but not in the same cell types as the cis-vaccenyl acetate binding protein LUSH. Our data support a model in which esterase 6 acts as a direct odorant degrading enzyme for many bioactive food esters, but not cis-vaccenyl acetate.
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