Evidence map›Paper›PMID 28393838›Full record

ArticleScientific reports2017

Functional Polymorphisms in Dopaminergic Genes Modulate Neurobehavioral and Neurophysiological Consequences of Sleep Deprivation.

Sebastian C Holst, Thomas Müller, Amandine Valomon, Britta Seebauer, Wolfgang Berger, Hans-Peter Landolt

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 39 citations in OpenAlex.

  1. Risk of excessive sleepiness in sleep restriction therapy and cognitive behavioral therapy for insomnia: a randomized controlled trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020
    Trial
  2. Effects of COMT genotype and tolcapone on lapses of sustained attention after sleep deprivation in healthy young men.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Interplay between insomnia, anxiety, and depression.World journal of psychiatry · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Sleep-Wake Neurobiology.Advances in experimental medicine and biology · 2021
    Review
  13. ADORA2A variation and adenosine ATranslational psychiatry · 2020
    Article
  14. Sleep deprivation, vigilant attention, and brain function: a review.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Neurobehavioral Effects and Biomarkers of Sleep Loss in Healthy Adults.Current neurology and neuroscience reports · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sebastian C HolstInstitute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.
Thomas MüllerInstitute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.
Amandine ValomonInstitute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.
Britta SeebauerInstitute of Medical Molecular Genetics, University of Zürich, Schlieren, Switzerland.
Wolfgang BergerZurich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.
Hans-Peter LandoltInstitute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.
University of Zurich · CHSwiss Integrative Center for Human Health · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sleep deprivation impairs cognitive performance and reliably alters brain activation in wakefulness and sleep. Nevertheless, the molecular regulators of prolonged wakefulness remain poorly understood. Evidence from genetic, behavioral, pharmacologic and imaging studies suggest that dopaminergic signaling contributes to the behavioral and electroencephalographic (EEG) consequences of sleep loss, although direct human evidence thereof is missing. We tested whether dopamine neurotransmission regulate sustained attention and evolution of EEG power during prolonged wakefulness. Here, we studied the effects of functional genetic variation in the dopamine transporter (DAT1) and the dopamine D

Indexed as

BehaviorPolymorphism, GeneticAdultDemographyDopamineDopamine Plasma Membrane Transport ProteinsElectroencephalographyFemaleGenotypeHumansMalePsychomotor PerformanceReceptors, Dopamine D2Sleep DeprivationTask Performance and AnalysisWakefulnessDopamineDopamine Plasma Membrane Transport ProteinsDRD2 protein, humanReceptors, Dopamine D2SLC6A3 protein, human

Identifiers

PMID28393838
PMCPMC5385564
OpenAlexW2606964637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.