SynthesisJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2018
Variability of physiological brain perfusion in healthy subjects - A systematic review of modifiers. Considerations for multi-center ASL studies.
Synthesis in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 4 of them syntheses that pooled it.
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Who cites it
69 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Arterial spin labeling MRI in patients undergoing carotid artery revascularization: a systematic review of the hemodynamic changes and clinical implications.European radiology · 2026Pooled it
- Arterial spin labelling magnetic resonance imaging and perfusion patterns in neurocognitive and other mental disorders: a systematic review.Neuroradiology · 2024Pooled it
- Measuring Quantitative Cerebral Blood Flow in Healthy Children: A Systematic Review of Neuroimaging Techniques.Journal of magnetic resonance imaging : JMRI · 2024Pooled it
- Effect of Acetylcholinesterase Inhibitors on Cerebral Perfusion and Cognition: A Systematic Review.Journal of Alzheimer's disease : JAD · 2023Pooled it
- Investigating resting brain perfusion abnormalities and disease target-engagement by intranasal oxytocin in women with bulimia nervosa and binge-eating disorder and healthy controls.Translational psychiatry · 2020Trial
- Reduced Cerebral Blood Flow in the Early Chronic Phase of Recurrent Concussion Among Female Collegiate-Aged Athletes.Human brain mapping · 2026Article
- Cerebral blood flow in a tri-ethnic population: insights from pCASL perfusion MRI.European radiology · 2026Article
- Spatially and temporally progressive hypoperfusion in Alzheimer's disease revealed by normative modeling.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of Posttreatment Hyperperfusion on Arterial Spin Labeling with Fluid-Attenuated Inversion Recovery Vascular Hyperintensity in Patients with Acute Ischemic Stroke after Endovascular Therapy.Cerebrovascular diseases extra · 2026Article
- Characterizing pre- and post-operative cerebral blood flow and transit time in pediatric moyamoya patients using multi-delay ASL and DSC MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Predictor value of pCASL maps on final core in acute ischemic stroke: an observational single‑center study.Neuroradiology · 2025Observational
- Early cognitive and quality of life changes after transfemoral transcatheter aortic valve replacement.Medicine and pharmacy reports · 2025Article
- Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids.Cell stem cell · 2025Article
- Brain perfusion and blood-brain barrier permeability in systemic lupus erythematosus patients: Associations with disease activity, cognitive dysfunction, fatigue and pain.Neuroimage. Reports · 2025Article
- Cerebral blood flow and cognitive functioning in patients undergoing transcatheter aortic valve implantation.EClinicalMedicine · 2025Article
- Imputation models and error analysis for phase contrast MR cerebral blood flow measurements in heterogeneous pediatric and adult populations.Frontiers in physiology · 2025Article
- Multi-cohort, multi-sequence harmonisation for cerebrovascular brain age.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Dynamically grading cerebral collateral circulation using 3D multi-inversion time arterial spin labeling in ischemic stroke: a comparison with digital subtraction angiography.Frontiers in neurology · 2025Article
- Mid-life association between cardiovascular risk factors and cerebral blood flow in a multi-ethnic population.Cerebral circulation - cognition and behavior · 2025Article
- Advantages and challenges of using arterial spin labelling MRI to monitor cerebral blood flow in multi-centre clinical trials of neurodegenerative disease: Experience from the RADAR study.Cerebral circulation - cognition and behavior · 2025Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quantitative measurements of brain perfusion are influenced by perfusion-modifiers. Standardization of measurement conditions and correction for important modifiers is essential to improve accuracy and to facilitate the interpretation of perfusion-derived parameters. An extensive literature search was carried out for factors influencing quantitative measurements of perfusion in the human brain unrelated to medication use. A total of 58 perfusion modifiers were categorized into four groups. Several factors (e.g., caffeine, aging, and blood gases) were found to induce a considerable effect on brain perfusion that was consistent across different studies; for other factors, the modifying effect was found to be debatable, due to contradictory results or lack of evidence. Using the results of this review, we propose a standard operating procedure, based on practices already implemented in several research centers. Also, a theory of 'deep MRI physiotyping' is inferred from the combined knowledge of factors influencing brain perfusion as a strategy to reduce variance by taking both personal information and the presence or absence of perfusion modifiers into account. We hypothesize that this will allow to personalize the concept of normality, as well as to reach more rigorous and earlier diagnoses of brain disorders.
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