ArticleJournal of thrombosis and haemostasis : JTH2017
Associations of coagulation factors IX and XI levels with incident coronary heart disease and ischemic stroke: the REGARDS study.
Article in Journal of thrombosis and haemostasis : JTH, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- Plasma Metabolites Link Dietary Patterns to Stroke Risk.Annals of neurology · 2023Trial
- Prognostic significance of coagulation factor activity in acute stroke: a retrospective cohort study.Frontiers in medicine · 2026Article
- Factor IX and incident hypertension in Black and White adults: the REasons for Geographic and Racial Differences in Stroke cohort.Journal of hypertension · 2025Article
- Factor XI levels and the risk of cardiovascular events: a systematic review and meta-analysis of case-control and cohort studies.Research and practice in thrombosis and haemostasis · 2025Article
- Omega-3 Fatty Acids and Risk of Ischemic Stroke in REGARDS.Translational stroke research · 2025Article
- Factor XI and Atrial Fibrillation: A Mismatched Pairing?European cardiology · 2025Article
- Acetylglutamine Differentially Associated with First-Time Versus Recurrent Stroke.Translational stroke research · 2024Observational
- Effect of Breastfeeding Duration on Coagulation in Women With and Without History of Gestational Diabetes Mellitus.The Journal of clinical endocrinology and metabolism · 2024Article
- Blood coagulation in Prediabetes clusters-impact on all-cause mortality in individuals undergoing coronary angiography.Cardiovascular diabetology · 2024Article
- The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet and Metabolites in Chronic Kidney Disease.Nutrients · 2024Article
- Plasma Metabolites and Life's Simple 7 in REGARDS.Stroke · 2024Article
- Coagulation factors II, V, VII, IX, X and XI and mortality - a cohort study.Research and practice in thrombosis and haemostasis · 2023Article
- Gut microbiota-associated metabolites and risk of ischemic stroke in REGARDS.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Association of Circulating Metabolites With Racial Disparities in Hypertension and Stroke in the REGARDS Study.Neurology · 2023Article
- Advantages of DES over BMS in Preventing the Risk of Myocardial Infarction, Ischemic Stroke, and Mortality in Various Populations.Journal of clinical medicine · 2022Article
- Association of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis.Scientific reports · 2022Article
- Nucleosides Associated With Incident Ischemic Stroke in the REGARDS and JHS Cohorts.Neurology · 2022Observational
- Associations of Hemostatic Variables with Cardiovascular Disease and Total Mortality: The Glasgow MONICA Study.TH open : companion journal to thrombosis and haemostasis · 2022Article
- Associations of coagulation factor X and XI with incident acute coronary syndrome and stroke: A nested case-control study.Journal of thrombosis and haemostasis : JTH · 2021Article
- Identifying Genetic and Biological Determinants of Race-Ethnic Disparities in Stroke in the United States.Stroke · 2020Review
Corrections and comments
- Commented on byRace.2017
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Essentials Coagulation factors (F) IX and XI have been implicated in cardiovascular disease (CVD) risk. We studied associations of FIX and FXI with incident coronary heart disease (CHD) and stroke. Higher FIX antigen was associated with incident CHD risk in blacks but not whites. Higher levels of FIX antigen may be a CHD risk factor among blacks. SUMMARY: Background Recent studies have suggested the importance of coagulation factor IX and FXI in cardiovascular disease (CVD) risk. Objectives To determine whether basal levels of FIX or FXI antigen were associated with the risk of incident coronary heart disease (CHD) or ischemic stroke. Patients/Methods The REasons for Geographic And Racial Differences in Stroke (REGARDS) study recruited 30 239 participants across the contiguous USA between 2003 and 2007. In a case-cohort study within REGARDS, FIX and FXI antigen were measured in participants with incident CHD (n = 609), in participants with incident ischemic stroke (n = 538), and in a cohort random sample (n = 1038). Hazard ratios (HRs) for CHD and ischemic stroke risk were estimated with Cox models per standard deviation higher FIX or FXI level, adjusted for CVD risk factors. Results In models adjusting for CHD risk factors, higher FIX levels were associated with incident CHD risk (HR 1.19; 95% confidence interval [CI] 1.01-1.40) and the relationship of higher FXI levels was slightly weaker (HR 1.15; 95% CI 0.97-1.36). When stratified by race, the HR of FIX was higher in blacks (HR 1.39; 95% CI 1.10-1.75) than in whites (HR 1.06; 95% CI 0.86-1.31). After adjustment for stroke risk factors, there was no longer an association of FIX levels with ischemic stroke, whereas the association of FXI levels with ischemic stroke was slightly attenuated. Conclusions Higher FIX antigen levels were associated with incident CHD in blacks but not in whites. FIX levels may increase CHD risk among blacks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.