ArticleJournal of clinical laboratory analysis2018
Resistin polymorphims, plasma resistin levels and obesity in Tunisian volunteers.
Article in Journal of clinical laboratory analysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Genetic Association of LEP Gene Polymorphisms with Obesity in Moroccan Individuals: Case-Control Study and Updated Meta-analysis.Biochemical genetics · 2023Pooled it
- Variants of Visceral Adipocytokine Genes in Obesity and Coronary Atherosclerosis: A Review.Current medicinal chemistry · 2026Review
- Association of resistin rs1862513, rs10401670 and rs3745367 polymorphisms with resistin level and insulin resistance in an Iranian type 2 diabetic population.Journal of diabetes and metabolic disorders · 2025Article
- Unraveling molecular interconnections and identifying potential therapeutic targets of significance in obesity-cancer link.Journal of the National Cancer Center · 2025Review
- Serum levels of anti-inflammatory/proinflammatory adipocytokines, and copper levels in overweight and obese women in an adult Mexican population.Hormones (Athens, Greece) · 2023Article
- Article
- Innate-Immunity Genes in Obesity.Journal of personalized medicine · 2021Review
- Obesity, not a high fat, high sucrose diet alone, induced glucose intolerance and cardiac dysfunction during pregnancy and postpartum.Scientific reports · 2021Article
- Impacts of RETN genetic polymorphism on breast cancer development.Journal of Cancer · 2020Article
- Genetic Basis of Obesity and Type 2 Diabetes in Africans: Impact on Precision Medicine.Current diabetes reports · 2019Review
- Role of resistin genetic variations in knee osteoarthritis pathogenesis, a cross sectional study.Molecular biology reports · 2019Article
- Leptin and Leptin receptor polymorphisms, plasma Leptin levels and obesity in Tunisian volunteers.International journal of experimental pathology · 2018Article
- Resistin polymorphims, plasma resistin levels and obesity in Tunisian volunteers.Journal of clinical laboratory analysis · 2018Article
- Deciphering the Relationship between Obesity and Various Diseases from a Network Perspective.Genes · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdipose tissue is an important endocrine organ that secretes a number of adipokines, like Resistin (RETN); it's an adipocytes-secreted cytokine and has been proposed as a link between obesity and diabetes. Many resistin gene polymorphisms were described and their implication in obesity was controversial. This study was to investigate the prevalence of single nucleotide polymorphisms (SNPs) in RETN gene 420C/G; 44G/A; 62G/A; 394C/G and 299 G/A and their association with Resistin level and obesity in Tunisian volunteers.
methodsWe recruited 169 nonobese (mean age=42.16-14.26 years; mean body mass index [BMI]=24.51-3.69 kg/m
resultsAfter adjustment for confounding parameters; the Odds Ratio (OR) of obesity associated with mutated genotypes at 420C/G compared with normal genotype was as: OR=2.17; 95% CI [1.28-3.68], P=.004. The serum Resistin levels present no significant association with all RETN polymorphisms and it was significantly associated with BMI (P=.047). In our haplotype analysis, one haplotype seems to be protective and one other seems to be the highest risk to obesity.
conclusionThe 420 C/G Polymorphism were associated with obesity and Leptin concentration in our population.
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Registered trials
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