ArticleCancer2017
Reduced rate of human papillomavirus infection and genetic overtransmission of TP53 72C polymorphic variant lower cervical cancer incidence.
Article in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Prevalence and genotypes' distribution of human papillomavirus among women in Saudi Arabia: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Association between theFrontiers in oncology · 2025Pooled it
- Epidemiology of Human Papillomavirus in Saudi Arabia: A Scoping Review of Prevalence, Genotypes, and Risk Factors.Journal of epidemiology and global health · 2025Article
- Knowledge, attitude, and perception of the parents toward HPV vaccine administration to their children in Saudi Arabia: a cross-sectional study.Frontiers in public health · 2025Article
- Innovative nomogram for cervical cancer prediction: integrating high-risk HPV infection,Frontiers in oncology · 2025Article
- An Evaluation of High-Risk HPV in Squamous Cell Carcinomas of the Lip in a South African Cohort.Head and neck pathology · 2024Article
- Human papillomavirus prevalence and genotypes in Gulf Cooperation Council countries: A scoping review 2017-2024.Qatar medical journal · 2024Article
- Analysis of E-cadherin (CDH1) Gene Polymorphism and Its Association with Cervical Cancer Risk in Bangladeshi Women.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Bimodal Age Distribution in Cancer Incidence.World journal of oncology · 2022Review
- Exploration of biomarkers for the diagnosis, treatment and prognosis of cervical cancer: a review.Discover oncology · 2022Review
- Elevated serum expression of p53 and association of TP53 codon 72 polymorphisms with risk of cervical cancer in Bangladeshi women.PloS one · 2021Article
- TP53 genetic polymorphisms and susceptibility to cervical cancer in Bangladeshi women: a case-control study.Molecular biology reports · 2020Article
- Cancer Prevention in Low-Resource Countries: An Overview of the Opportunity.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2020Article
- Article
- Interaction between TP53 and XRCC1 increases susceptibility to cervical cancer development: a case control study.BMC cancer · 2019Article
- Exploring the Causes of the Low Incidence of Cervical Cancer in Western AsiaAsian Pacific journal of cancer prevention : APJCP · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCervical cancer is a predominantly human papillomavirus (HPV)-driven disease worldwide. However, its incidence is unexplainably low in western Asia, including Saudi Arabia. Using this paradigm, we investigated the role of HPV infection rate and host genetic predisposition in TP53 G72C single nucleotide polymorphism (SNP) presumed to affect cancer incidence.
methodsPatients treated between 1990 and 2012 were reviewed, and a series of 232 invasive cervical cancer cases were studied and compared with 313 matched controls without cancer. SNP was genotyped by way of direct sequencing. HPV linear array analysis was used to detect and genotype HPV in tumor samples.
resultsThe incidence of cervical cancer revealed bimodal peaks at 42.5 years, with a slighter rebound at 60.8 years. Among all cases, 77% were HPV-positive and 16 HPV genotypes were detected-mostly genotypes 16 (75%) and 18 (9%)-with no difference by age, histology, or geographical region. Although the TP53 G72C genotype was not associated with overall cervical cancer risk, it was significantly associated with HPV positivity (odds ratio, 0.57; 95% confidence interval, 0.36-0.90; P = .016). Furthermore, the variant C allele was significantly overtransmitted in the population (P < .0003).
conclusionCervical cancer incidence displays bimodal curve peaking at a young age with secondary rebound at older age. The combination of relative low HPV infection and variant TP53 72C allele overtransmission provide a plausible explanation for the low incidence of cervical cancer in our population. Therefore, HPV screening and host SNP genotyping may provide more relevant biomarkers to gauge the risk of developing cervical cancer. Cancer 2017;123:2459-66. © 2017 American Cancer Society.
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