Evidence map›Paper›PMID 28393350›Full record

Trial reportJournal of child psychology and psychiatry, and allied disciplines2017

Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years.

Jonathan Green, Andrew Pickles, Greg Pasco, Rachael Bedford, Ming Wai Wan, Mayada Elsabbagh, Vicky Slonims, Teea Gliga, Emily Jones, Celeste Cheung and 3 more

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of child psychology and psychiatry, and allied disciplines, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06512649 (Early Recognition and Intervention in Siblings at High-risk for Neurodevelopmental Disorder), which is not on this map. Cited by 130 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 9 pooled it
18.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06512649 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Early Recognition and Intervention in Siblings at High-risk for Neurodevelopmental Disorder

TypeinterventionalSponsorFondazione Don Carlo Gnocchi ETSRan2023 to 2026Enrolled48ConditionsNeurodevelopmental Disorders, Autism Spectrum DisorderArmsEarly intervention, Active monitoring
3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 9 syntheses or guidelines pooled it, 319 citations in OpenAlex.

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  3. Social motor synchrony in autism spectrum conditions: A systematic review.Autism : the international journal of research and practice · 2024
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70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Jonathan GreenSocial Development Research Group, School of Biological Sciences, University of Manchester, Manchester, UK.
Andrew PicklesInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Greg PascoInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Rachael BedfordInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Ming Wai WanSchool of Health Sciences, University of Manchester, Manchester, UK.
Mayada ElsabbaghCentre for Brain and Cognitive Development, Birkbeck College, London, UK.
Vicky SlonimsEvelina London Children's Hospital and King's College London Neurosciences Centre, London, UK.
Teea GligaCentre for Brain and Cognitive Development, Birkbeck College, London, UK.
Emily JonesCentre for Brain and Cognitive Development, Birkbeck College, London, UK.ORCID http://orcid.org/0000-0001-5747-9540
Celeste CheungCentre for Brain and Cognitive Development, Birkbeck College, London, UK.
Tony CharmanInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Mark JohnsonCentre for Brain and Cognitive Development, Birkbeck College, London, UK.
British Autism Study of Infant Siblings (BASIS) Team
King's College London · GBBirkbeck, University of London · GBManchester Academic Health Science Centre · GBMcGill University · CAUniversity of Manchester · GB

Funding

Medical Research Council G0701484Medical Research Council MR/K021389/1Wellcome Trust
6 · The paper itself

Abstract

backgroundThere has been increasing interest in the potential for pre-emptive interventions in the prodrome of autism, but little investigation as to their effect.

methodsA two-site, two-arm assessor-blinded randomised controlled trial (RCT) of a 12-session parent-mediated social communication intervention delivered between 9 and 14 months of age (Intervention in the British Autism Study of Infant Siblings-Video Interaction for Promoting Positive Parenting), against no intervention. Fifty-four infants (28 intervention, 26 nonintervention) at familial risk of autism but not otherwise selected for developmental atypicality were assessed at 9-month baseline, 15-month treatment endpoint, and 27- and 39-month follow-up. PRIMARY OUTCOME: severity of autism prodromal symptoms, blind-rated on Autism Observation Schedule for Infants or Autism Diagnostic Observation Schedule 2nd Edition across the four assessment points. SECONDARY OUTCOMES: blind-rated parent-child interaction and child language; nonblind parent-rated communication and socialisation. Prespecified intention-to-treat analysis combined estimates from repeated measures within correlated regressions to estimate the overall effect of the infancy intervention over time.

resultsEffect estimates in favour of intervention on autism prodromal symptoms, maximal at 27 months, had confidence intervals (CIs) at each separate time point including the null, but showed a significant overall effect over the course of the intervention and follow-up period (effect size [ES] = 0.32; 95% CI 0.04, 0.60; p = .026). Effects on proximal intervention targets of parent nondirectiveness/synchrony (ES = 0.33; CI 0.04, 0.63; p = .013) and child attentiveness/communication initiation (ES = 0.36; 95% CI 0.04, 0.68; p = .015) showed similar results. There was no effect on categorical diagnostic outcome or formal language measures.

conclusionsFollow-up to 3 years of the first RCT of a very early social communication intervention for infants at familial risk of developing autism has shown a treatment effect, extending 24 months after intervention end, to reduce the overall severity of autism prodromal symptoms and enhance parent-child dyadic social communication over this period. We highlight the value of extended follow-up and repeat assessment for early intervention trials.

Indexed as

CommunicationInterpersonal RelationsParent-Child RelationsParentingProdromal SymptomsAutism Spectrum DisorderChild, PreschoolEarly Intervention, EducationalEducation, NonprofessionalFemaleHumansLanguage DevelopmentLongitudinal StudiesMaleOutcome Assessment, Health CareSingle-Blind Methodautismautism spectrum disorderhigh-risk siblingsparent-mediated interventionPre-emptive interventionprevention trials

Identifiers

PMID28393350
PMCPMC5724485
OpenAlexW2605716357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.