Evidence map›Paper›PMID 28393317›Full record

Trial reportQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2017

Impact of an electronic monitoring device and behavioral feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial.

E Ann Yeh, Stephanie A Grover, Victoria E Powell, Gulay Alper, Brenda L Banwell, Kim Edwards, Mark Gorman, Jennifer Graves, Timothy E Lotze, Jean K Mah and 8 more

Erratum issuedOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. The State of the Art of Pediatric Multiple Sclerosis.International journal of molecular sciences · 2023
    Review
  4. The Economic and Humanistic Burden of Pediatric-Onset Multiple Sclerosis.Journal of health economics and outcomes research · 2022
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Newer Treatment Approaches in Pediatric-Onset Multiple Sclerosis.Current treatment options in neurology · 2019
    Review
  10. Review
  11. Review
  12. A multicenter, observational, prospective study of self- and parent-reported quality of life in adolescent multiple sclerosis patients self-administering interferon-β1a using RebiSmart™-the FUTURE study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017
    Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 2 countries.

E Ann YehPediatric MS and Neuroinflammatory Disorders Program, Division of Neurology, Department of Pediatrics, Neuroscience and Mental Health, Hospital for Sick Children Research Institute, Hospital for Sick Children, 555 University Avenue, Rm 6D33, Toronto, ON, M5G1X8, Canada. ann.yeh@sickkids.ca.
Stephanie A GroverPediatric MS and Neuroinflammatory Disorders Program, Division of Neurology, Department of Pediatrics, Neuroscience and Mental Health, Hospital for Sick Children Research Institute, Hospital for Sick Children, 555 University Avenue, Rm 6D33, Toronto, ON, M5G1X8, Canada.
Victoria E PowellDeltaQuest Foundation Inc., 31 Mitchell Road, Concord, MA, 01742, USA.
Gulay AlperChildren's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA, 15224, USA.
Brenda L BanwellDivision of Neurology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.
Kim EdwardsDepartment of Psychiatry, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G1X8, Canada.
Mark GormanBoston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.
Jennifer GravesUniversity of California San Francisco, 505 Parnassus Avenue, San Francisco, CA, 94143, USA.
Timothy E LotzeTexas Children's Hospital, Baylor College of Medicine, 6621 Fannin Street, Houston, TX, 77030, USA.
Jean K MahAlberta Children's Hospital, 2888 Shanganappi Trail NW, Calgary, AB, T3B 6A8, Canada.
Lauren MednickBoston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.
Jayne NessUniversity of Alabama at Birmingham, 1720 2nd Avenue, Birmingham, AL, 35294, USA.
Maya ObadiaELLICSR: Health, Wellness, and Cancer Survivorship Centre, University Health Network, 585 University Avenue, Toronto, ON, M5G 2C4, Canada.
Ruth SlaterDepartment of Psychiatry, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G1X8, Canada.
Amy WaldmanDivision of Neurology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.
Emmanuelle WaubantUniversity of California San Francisco, 505 Parnassus Avenue, San Francisco, CA, 94143, USA.
Carolyn E SchwartzDeltaQuest Foundation Inc., 31 Mitchell Road, Concord, MA, 01742, USA.
Pediatric MS Adherence Study Group
Boston Children's Hospital · USChildren's Hospital of Philadelphia · USHospital for Sick Children · CATufts University · USUniversity Health Network · CABaylor College of Medicine · USUniversity of California, San Francisco · USUniversity of Pittsburgh · US

Funding

Development of visual and neurologic outcome measures in pediatric MSK23NS069806 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI WALDMAN, AMY TARA · 2012 to 2016
$924k
National Multiple Sclerosis Society HC 0148NINDS NIH HHS K23 NS069806
6 · The paper itself

Abstract

purposeTo report the results of a randomized controlled trial using an electronic monitoring device (EM) plus a motivational interviewing (MI) intervention to enhance adherence to disease-modifying therapies (DMT) in pediatric MS.

methodsFifty-two youth with MS (16.03 ± 2.2 years) were randomized to receive either MI (n = 25) (target intervention) or a MS medication video (n = 27) (attention control). Primary endpoint was change in adherence. Secondary outcomes included changes in quality of life, well-being and self-efficacy. Random effects modeling and Cohen's effect size computation evaluated intervention impact.

resultsLongitudinal random effect models revealed that the MI group decreased their EM adherence (GroupxTime interaction = -0.19), while increasing frequency of parental DMT reminder (26.01)/administration (11.69). We found decreased EM use in the MI group at 6 months (Cohen's d = -0.61), but increased pharmacy refill adherence (d = 0.23). Parental reminders about medication increased in MI subjects vs controls (d = 0.59 at 3 months; d = 0.70 at 6 months). We found increases in self-reported adherence (d = 0.21) at 3 but not 6 months, fewer barriers to adherence at three (d = -0.58) and six months (d = -0.31), better physical (d = 0.23 at 3 months; d = 0.45 at 6 months), emotional (d = 0.25 at 3 months) and self-efficacy function (d = 0.55 at 3 months; 0.48 at 6 months), but worse well-being, including self-acceptance (d = -0.53 at 6 months) and environmental mastery (d = -0.42 at 3 and 6 months) in intervention as compared to control patients.

conclusionsParticipants receiving MI + EM experienced worsening on objective measures of adherence and increased parental involvement, but improved on some self- and parent-reported measures. MI participants reported improvements in quality of life and self-efficacy, but worsened well-being.

Indexed as

AdolescentFemaleHealth BehaviorHumansMaleMedication AdherenceMultiple SclerosisQuality of LifeBehavioral interventionMultiple sclerosisPediatricQuality of lifeWell-being

Identifiers

PMID28393317
PMCPMC6149210
OpenAlexW2604288382

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.