Evidence map›Paper›PMID 28393316›Full record

ArticleJournal of endocrinological investigation2017

Profiling of selenium absorption and accumulation in healthy subjects after prolonged L-selenomethionine supplementation.

C Di Dato, D Gianfrilli, E Greco, M Astolfi, S Canepari, A Lenzi, A M Isidori, E Giannetta

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Article in Journal of endocrinological investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Urinary Mercury Levels and Predictors of Exposure among a Group of Italian Children.International journal of environmental research and public health · 2020
    Article
  6. Element Levels and Predictors of Exposure in the Hair of Ethiopian Children.International journal of environmental research and public health · 2020
    Article
  7. Biomonitoring of Mercury in Hair among a Group of Eritreans (Africa).International journal of environmental research and public health · 2020
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

C Di DatoDepartment of Experimental Medicine, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
D GianfrilliDepartment of Experimental Medicine, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
E GrecoCenter for Reproductive Medicine, European Hospital, Rome, Italy.
M AstolfiChemistry Department, "Sapienza" University of Rome, Rome, Italy.
S CanepariChemistry Department, "Sapienza" University of Rome, Rome, Italy.
A LenziDepartment of Experimental Medicine, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
A M IsidoriDepartment of Experimental Medicine, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
E GiannettaDepartment of Experimental Medicine, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy. elisa.giannetta@uniroma1.it.
Sapienza University of Rome · ITPoliclinico Umberto I · ITEuropean Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAutoimmune thyroiditis and its complications for the reproductive system are a growing problem. Selenium is a common ingredient in numerous food supplements recommended for thyroiditis and pregnancy. A fast, simple method to measure serum selenium concentration will improve knowledge of its pharmacokinetics and toxicity.

aimTo validate a useful method to measure serum selenium concentration and to study selenium absorption and accumulation in a prospective interventional study of prolonged treatment.

methodsThirty healthy volunteers received a single dose of L-selenomethionine one tablet (83 mcg) (Phase 1), a single dose of two tablets (Phase 2), and two tablets daily for 14 days (Phase 3). Total selenium and selenium time profiles were generated by serial sampling (T0, T3, T6, T12, and T24 hours after ingestion-Phases 1 and 2; and T0 and T24 hours-Phase 3). Selenium concentration was investigated by open-vessel acid digestion of small serum volumes followed by hydride generation atomic fluorescence spectroscopy analysis.

resultsThere was a significant increase in serum selenium concentration (mcg/L) in all treatment phases. Significantly increased levels were reached at T3 in Phase 1 (baseline: 76.5 ± 2.47; T3: 82.8 ± 3.28) and at T6 in Phase 2 (83.8 ± 3.46). They remained significantly increased at T12 in Phase 1 and T24 in Phase 2 (79.03 ± 2.69). There was significant selenium accumulation after prolonged intake (14 days) (102.13 ± 5.61).

conclusionsProlonged selenomethionine administration increases circulating blood selenium concentration and hydride generation atomic fluorescence spectroscopy enables its accurate quantification.

Indexed as

Dietary SupplementsAdultFemaleHealthy VolunteersHumansMaleProspective StudiesSeleniumSelenomethionineSeleniumSelenomethionineAutoimmune thyroiditisHydride generation atomic fluorescence spectroscopyPregnancyReproductive systemSerum selenium concentration

Identifiers

PMID28393316
OpenAlexW2605082788

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.