Evidence map›Paper›PMID 28393139›Full record

ArticleChronic stress (Thousand Oaks, Calif.)2017

Effects of Acute Confinement Stress-induced Hypothalamic-Pituitary Adrenal Axis Activation and Concomitant Peripheral and Central Transforming Growth Factor-β1 Measures in Nonhuman Primates.

Jeremy D Coplan, Srinath Gopinath, Chadi G Abdallah, Jeffrey Margolis, Wei Chen, Bruce A Scharf, Leonard A Rosenblum, Olcay A Batuman, Eric L P Smith

Open access · goldAbstract read
In one paragraph

Article in Chronic stress (Thousand Oaks, Calif.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jeremy D CoplanDepartment of Psychiatry & Behavioral Science, Division of Neuropsychopharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY, USA.
Srinath GopinathDepartment of Psychiatry & Behavioral Science, Division of Neuropsychopharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Clinical Neurosciences Division, National Center for PTSD, West Haven, CT, USA.
Chadi G AbdallahDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Clinical Neurosciences Division, National Center for PTSD, West Haven, CT, USA.
Jeffrey MargolisDepartment of Psychiatry & Behavioral Science, Division of Neuropsychopharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY, USA.
Wei ChenDepartment of Psychiatry & Behavioral Science, Division of Neuropsychopharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY, USA.
Bruce A ScharfDepartment of Psychiatry & Behavioral Science, Division of Neuropsychopharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY, USA.
Leonard A RosenblumDepartment of Psychiatry & Behavioral Science, Division of Neuropsychopharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY, USA.
Olcay A BatumanDepartment of Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Eric L P SmithDivision of hematology, SUNY Downstate Medical Center, Broioklyn, NY, USA.
SUNY Downstate Health Sciences University · USState University of New York · USNational Center for PTSD · USYale University · US

Funding

ADVERSE EARLY REARING &GLUTAMATERGIC FUNCTIONR01MH059990 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI COPLAN, JEREMY D · 2000 to 2003
$1.1M
Examining The Effect Of Ketamine On Glutamate/Glutamine CyclingK23MH101498 · NIMH · YALE UNIVERSITY · PI ABDALLAH, CHADI · 2013 to 2017
$879k
NIMH NIH HHS K23 MH101498
6 · The paper itself

Abstract

Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine with anti-inflammatory, immunosuppressive and neuroprotective properties. The hypothalamic-pituitary-adrenal (HPA) axis and immune system exert bidirectional influences on each other, via cortisol and TGF-β1, but the exact nature of the interaction is not well characterized. The current study examined the effects, in bonnet macaques (

Indexed as

cerebrospinal fluidcortisolcytokinedexamethasoneglucocorticoidnonhuman primatestresstransforming growth factor-β1

Identifiers

PMID28393139
PMCPMC5381663
OpenAlexW2588824736

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.