ArticleGynecologic oncology reports2017
Hormonal based treatment of ovarian anaplastic ependymoma with anastrozole.
Article in Gynecologic oncology reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Surgical debulking with fertility preservation in primary extra-neural ependymoma presenting with widespread peritoneal and intra-abdominal disease: Case report and literature review.Gynecologic oncology reports · 2026Article
- Ovarian ependymoma presenting in pregnancy: a case report and literature review.BMC pregnancy and childbirth · 2020Review
- Individualized treatment for a case of recurrent ovarian ependymoma.OncoTargets and therapy · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOvarian anaplastic ependymoma is a rare gynecologic malignancy that poses diagnostic and treatment challenges. Treatment of sub-optimally debulked disease usually portends poor prognosis. Molecular testing of tumor specimen can identify more specific targets for additional therapy such as estrogen and progesterone receptors (ER/PR). CASE: A 29-year-old woman presented with incidental finding of large bilateral adnexal masses and elevated CA 125. Biopsy proved anaplastic ovarian ependymoma with high ER/PR expression. She underwent sub-optimal surgical debulking followed by adjuvant chemotherapy with bleomycin, etoposide and cisplatin (BEP) which resulted in a partial response. Due to extensive residual disease she has been maintained on anastrozole for over fifteen months without increased tumor burden. Targeted somatic mutation testing was negative for all high risk clinically useful variants.
conclusionAromatase inhibitors may be considered in patients with extra-axial anaplastic ependymoma and can produce prolonged stable disease.
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