ArticlePhotoacoustics2017
Photoacoustic signal characterization of cancer treatment response: Correlation with changes in tumor oxygenation.
Article in Photoacoustics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Quantitative ultrasound and photoacoustic assessments of red blood cell aggregation in the human radial artery.Photoacoustics · 2025Article
- Ultrasound-guided photoacoustic image annotation toolkit in MATLAB (PHANTOM) for preclinical applications.Photoacoustics · 2025Article
- Vascular regional analysis unveils differential responses to anti-angiogenic therapy in pancreatic xenografts through macroscopic photoacoustic imaging.Theranostics · 2025Article
- Ultrasound-guided Photoacoustic image Annotation Toolkit in MATLAB (PHANTOM) for preclinical applications.bioRxiv : the preprint server for biology · 2023Article
- Niche preclinical and clinical applications of photoacoustic imaging with endogenous contrast.Photoacoustics · 2023Review
- A review of a strategic roadmapping exercise to advance clinical translation of photoacoustic imaging: From current barriers to future adoption.Photoacoustics · 2023Review
- Application of photoacoustic computed tomography in biomedical imaging: A literature review.Bioengineering & translational medicine · 2023Review
- Photoacoustic graphic equalization and application in characterization of red blood cell aggregates.Photoacoustics · 2022Article
- Assessment of Nanoparticle-Mediated Tumor Oxygen Modulation by Photoacoustic Imaging.Biosensors · 2022Review
- 3D Ultrasound-Guided Photoacoustic Imaging to Monitor the Effects of Suboptimal Tyrosine Kinase Inhibitor Therapy in Pancreatic Tumors.Frontiers in oncology · 2022Article
- Broadband surface plasmon resonance sensor for fast spectroscopic photoacoustic microscopy.Photoacoustics · 2021Article
- Anti-HER2 PLGA-PEG polymer nanoparticle containing gold nanorods and paclitaxel for laser-activated breast cancer detection and therapy.Biomedical optics express · 2021Article
- Role of blood oxygenation saturation in ovarian cancer diagnosis using multi-spectral photoacoustic tomography.Journal of biophotonics · 2021Article
- A Robust Oxygen Microbubble Radiosensitizer for Iodine-125 Brachytherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Photoacoustic Computed Tomography of Breast Cancer in Response to Neoadjuvant Chemotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Tunable blood oxygenation in the vascular anatomy of a semi-anthropomorphic photoacoustic breast phantom.Journal of biomedical optics · 2021Article
- Photoacoustic imaging biomarkers for monitoring biophysical changes during nanobubble-mediated radiation treatment.Photoacoustics · 2020Article
- Photoacoustic imaging of kidney fibrosis for assessing pretransplant organ quality.JCI insight · 2020Article
- Photoacoustic Imaging in Tissue Engineering and Regenerative Medicine.Tissue engineering. Part B, Reviews · 2020Review
- Photoacoustic simulations of microvascular bleeding: spectral analysis and its application for monitoring vascular-targeted treatments.Journal of biomedical optics · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frequency analysis of the photoacoustic radiofrequency signals and oxygen saturation estimates were used to monitor the in-vivo response of a novel, thermosensitive liposome treatment. The liposome encapsulated doxorubicin (HaT-DOX) releasing it rapidly (<20 s) when the tumor was exposed to mild hyperthermia (43 °C). Photoacoustic imaging (VevoLAZR, 750/850 nm, 40 MHz) of EMT-6 breast cancer tumors was performed 30 min pre- and post-treatment and up to 7 days post-treatment (at 2/5/24 h timepoints). HaT-DOX-treatment responders exhibited on average a 22% drop in oxygen saturation 2 h post-treatment and a decrease (45% at 750 nm and 73% at 850 nm) in the slope of the normalized PA frequency spectra. The spectral slope parameter correlated with treatment-induced hemorrhaging which increased the optical absorber effective size via interstitial red blood cell leakage. Combining frequency analysis and oxygen saturation estimates differentiated treatment responders from non-responders/control animals by probing the treatment-induced structural changes of blood vessel.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.