ArticleNeuroImage. Clinical2017
Neural substrates of motor and cognitive dysfunctions in SCA2 patients: A network based statistics analysis.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Cerebellar Contributions to Cognitive Affective Function and Postural Tremor in Neurological Wilson's Disease.Cerebellum (London, England) · 2026Article
- The Pattern and Stages of Atrophy in Spinocerebellar Ataxia Type 2: Volumetrics from ENIGMA-Ataxia.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Subtypes of cognitive impairment in cerebellar disease identified by cross-diagnostic cluster-analysis: results from a German multicenter study.Journal of neurology · 2024Article
- The Pattern and Staging of Brain Atrophy in Spinocerebellar Ataxia Type 2 (SCA2): MRI Volumetrics from ENIGMA-Ataxia.bioRxiv : the preprint server for biology · 2024Article
- The Cerebellar Cognitive Affective/Schmahmann Syndrome Scale in Spinocerebellar Ataxias.Cerebellum (London, England) · 2024Article
- Compressed cerebellar functional connectome hierarchy in spinocerebellar ataxia type 3.Human brain mapping · 2024Article
- Disability in cerebellar ataxia syndromes is linked to cortical degeneration.Journal of neurology · 2023Article
- The rising role of cognitive reserve and associated compensatory brain networks in spinocerebellar ataxia type 2.Journal of neurology · 2023Article
- Altered brain white matter structural motor network in spinocerebellar ataxia type 3.Annals of clinical and translational neurology · 2023Article
- "Biomedicines · 2022Article
- Cognitive Decline Is Closely Associated with Ataxia Severity in Spinocerebellar Ataxia Type 2: a Validation Study of the Schmahmann Syndrome Scale.Cerebellum (London, England) · 2022Article
- Comparison of Cerebellar Grey Matter Alterations in Bipolar and Cerebellar Patients: Evidence from Voxel-Based Analysis.International journal of molecular sciences · 2021Article
- MR imaging and spectroscopy in degenerative ataxias: toward multimodal, multisite, multistage monitoring of neurodegeneration.Current opinion in neurology · 2020Review
- The basal ganglia and the cerebellum in human emotion.Social cognitive and affective neuroscience · 2020Review
- Functional Changes of Mentalizing Network in SCA2 Patients: Novel Insights into Understanding the Social Cerebellum.Cerebellum (London, England) · 2020Article
- Neuroimaging Biomarkers in SCA2 Gene Carriers.International journal of molecular sciences · 2020Review
- The Cerebellar Cognitive Affective/Schmahmann Syndrome: a Task Force Paper.Cerebellum (London, England) · 2020Review
- The Relationships Between Ataxia and Cognition in Spinocerebellar Ataxia Type 2.Cerebellum (London, England) · 2020Article
- Age of onset determines intrinsic functional brain architecture in Friedreich ataxia.Annals of clinical and translational neurology · 2020Article
- Cerebello-Cortical Alterations Linked to Cognitive and Social Problems in Patients With Spastic Paraplegia Type 7: A Preliminary Study.Frontiers in neurology · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disease characterized by a progressive cerebellar syndrome, which can be isolated or associated with extracerebellar signs. It has been shown that patients affected by SCA2 present also cognitive impairments and psychiatric symptoms. The cerebellum is known to modulate cortical activity and to contribute to distinct functional networks related to higher-level functions beyond motor control. It is therefore conceivable that one or more networks, rather than isolated regions, may be dysfunctional in cerebellar degenerative diseases and that an abnormal connectivity within specific cerebello-cortical regions might explain the widespread deficits typically observed in patients. In the present study, the network-based statistics (NBS) approach was used to assess differences in functional connectivity between specific cerebellar and cerebral "nodes" in SCA2 patients. Altered inter-nodal connectivity was found between more posterior regions in the cerebellum and regions in the cerebral cortex clearly related to cognition and emotion. Furthermore, more anterior cerebellar lobules showed altered inter-nodal connectivity with motor and somatosensory cerebral regions. The present data suggest that in SCA2 a cerebellar dysfunction affects long-distance cerebral regions and that the clinical symptoms may be specifically related with connectivity changes between motor and non-motor cerebello-cortical nodes.
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