ArticleTranslational vision science & technology2017
The Effect of Retinal Melanin on Optical Coherence Tomography Images.
Article in Translational vision science & technology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 38 citations in OpenAlex.
- Light-induced modifications of the outer retinal hyperreflective layers on spectral-domain optical coherence tomography in humans: an experimental study.Acta ophthalmologica · 2021Trial
- Histology correlated adaptive optics polarisation sensitive optical coherence tomography.Biomedical optics express · 2026Article
- Prognostic Ability of Automated RPE Sinuosity for Late AMD Supersedes Qualitative Outer Retinal Band Assessment.Investigative ophthalmology & visual science · 2026Article
- Pigmentation and Retinal Pigment Epithelium Thickness: A Study of the Phenotypic and Genotypic Relationships Between Ocular and Extraocular Pigmented Tissues.Pigment cell & melanoma research · 2025Article
- The USH3A causative gene clarin1 functions in Müller glia to maintain retinal photoreceptors.PLoS genetics · 2025Article
- Distinct Phenotypic Consequences of Pathogenic Mutants Associated with Late-Onset Retinal Degeneration.The American journal of pathology · 2023Article
- Ultrahigh Resolution OCT Markers of Normal Aging and Early Age-related Macular Degeneration.Ophthalmology science · 2023Article
- Ocular Pigmentation Impact on Retinal Versus Choroidal Optical Coherence Tomography Imaging in Preterm Infants.Translational vision science & technology · 2023Article
- Evaluation of Retinal Layers and Choroidal Structures Using Optical Coherence Tomography in Alopecia Areata.Medeniyet medical journal · 2023Article
- Optical Coherence Tomography Is a Promising Tool for Zebrafish-Based Research-A Review.Bioengineering (Basel, Switzerland) · 2022Review
- Bilateral asymptomatic macular hypopigmentation in a young woman: multimodal imaging and pathogenetic hypothesis.American journal of ophthalmology case reports · 2022Article
- Comparison of choroidal hyperreflective spots on optical coherence tomography images between both eyes of normal subjects.Quantitative imaging in medicine and surgery · 2022Article
- In Vivo Imaging of Newt Lens Regeneration: Novel Insights Into the Regeneration Process.Translational vision science & technology · 2021Article
- Visible Light Optical Coherence Tomography (OCT) Quantifies Subcellular Contributions to Outer Retinal Band 4.Translational vision science & technology · 2021Article
- In Situ Morphologic and Spectral Characterization of Retinal Pigment Epithelium Organelles in Mice Using Multicolor Confocal Fluorescence Imaging.Investigative ophthalmology & visual science · 2020Article
- Cellular-Scale Imaging of Transparent Retinal Structures and Processes Using Adaptive Optics Optical Coherence Tomography.Annual review of vision science · 2020Review
- Noninvasive Imaging of Cone Ablation and Regeneration in Zebrafish.Translational vision science & technology · 2020Article
- Atlas of Human Retinal Pigment Epithelium Organelles Significant for Clinical Imaging.Investigative ophthalmology & visual science · 2020Article
- Longitudinal Structural and Microvascular Observation in RCS Rat Eyes Using Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2020Article
- Quantifying the Separation Between the Retinal Pigment Epithelium and Bruch's Membrane using Optical Coherence Tomography in Patients with Inherited Macular Degeneration.Translational vision science & technology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeWe assessed the effect of melanin on the appearance of hyperreflective outer retinal bands in optical coherence tomography (OCT) images.
methodsA total of 23 normal subjects and 51 patients with albinism were imaged using the Bioptigen high-resolution spectral-domain OCT. In addition, three wild type, three albino (
resultsThe foveal RPE/BrM appeared as two bands in 71% of locations in patients with albinism and 45% of locations in normal subjects (
conclusionsThe hyperreflective outer retinal bands in OCT images are highly variable in appearance. We showed that melanin is a major contributor to the intensity and width of the RPE band on OCT. One should use caution in extrapolating findings from OCT images of one or even a few individuals to define the absolute anatomic correlates of the hyperreflective outer retinal bands in OCT images. TRANSLATIONAL RELEVANCE: Melanin affects the appearance of the outer retinal bands in OCT images. Use of animal models may help dissect the anatomic correlates of the complex reflective signals in OCT retinal images.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.