Evidence map›Paper›PMID 28392965›Full record

ArticleBone research2017

Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis.

Qin Bian, Lei Ma, Amit Jain, Janet L Crane, Khaled Kebaish, Mei Wan, Zhengdong Zhang, X Edward Guo, Paul D Sponseller, Cheryle A Séguin and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 124 citations in OpenAlex.

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  13. Mechanistic study on components ofFrontiers in cell and developmental biology · 2026
    Article
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Qin BianDepartment of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University, Baltimore, MD, USA; Institute of Spine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China.
Lei MaDepartment of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University , Baltimore, MD, USA.
Amit JainDepartment of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University , Baltimore, MD, USA.
Janet L CraneDepartment of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA.
Khaled KebaishDepartment of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University , Baltimore, MD, USA.
Mei WanDepartment of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University , Baltimore, MD, USA.
Zhengdong ZhangDepartment of Biomedical Engineering, Columbia University , NY, USA.
X Edward GuoDepartment of Biomedical Engineering, Columbia University , NY, USA.
Paul D SponsellerDepartment of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University , Baltimore, MD, USA.
Cheryle A SéguinDepartments of Physiology and Pharmacology, University of Western Ontario , London, Canada.
Lee H RileyDepartment of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University , Baltimore, MD, USA.
Yongjun WangInstitute of Spine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine , Shanghai, PR China.
Xu CaoDepartment of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University , Baltimore, MD, USA.
Johns Hopkins Medicine · USJohns Hopkins University · USColumbia University · USLonghua Hospital Shanghai University of Traditional Chinese Medicine · CNWestern University · CA

Funding

Temporal-spatial Regulation of MSCs by IGF-1K08AR064833 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CRANE, JANET · 2014 to 2018
$650k
NIAMS NIH HHS K08 AR064833
6 · The paper itself

Abstract

Intervertebral disc (IVD) degeneration is the leading cause of disability with no disease-modifying treatment. IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal (NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α

Identifiers

PMID28392965
PMCPMC5360159
OpenAlexW2600246255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.