ArticleIranian journal of basic medical sciences2017
The effect of caffeine on orthodontic tooth movement in rats.
Article in Iranian journal of basic medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Under pressure-mechanisms and risk factors for orthodontically induced inflammatory root resorption: a systematic review.European journal of orthodontics · 2023Pooled it
- Integrative Computational and Experimental Approaches Reveal the Protective Role of Moderate Caffeine Intake Against Apical Periodontitis Induced Bone Loss.International endodontic journal · 2026Article
- The effects of splinting wire material and dimension on ankylosis and root resorption in luxated incisors: a rodent histological study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Pharmacological Modulation of Orthodontic Tooth Movement: Mechanisms, Clinical Implications, and Emerging Therapeutic Approaches. A Review.Clinical, cosmetic and investigational dentistry · 2026Review
- Caffeine displays dual effect on RANKL-induced osteoclast differentiation and bone resorption activity via adenosine receptors in RAW 264.7 cells.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2025Article
- The Effect of Heparin on Bone Metabolism and Orthodontic Tooth Movement in Rats.Clinical and experimental dental research · 2025Article
- Effect of Caffeine Injection on Orthodontic Tooth Movement in Rats: An Experimental Study on Rats.International journal of dentistry · 2022Article
- Cocoa administration may accelerate orthodontic tooth movement by inducing osteoclastogenesis in rats.Iranian journal of basic medical sciences · 2019Article
- Article
- Comparison of routine and microwave-assisted decalcification of bone with or without teeth: A histologic study.Dental research journalArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesto determine the effect of different doses of caffeine on orthodontic tooth movement (OTM) in rats. MATERIALS AND
methodsForty male 250-300 g Sprague-Dawley rats were randomly divided into four groups of ten animals each and received 0 (control), 1 g/l, 2 g/l and 3 g/l caffeine in tap water for 3 days. Orthodontic appliances were ligated between the maxillary first molars and incisors on the 4th day of the study period. All rats were sacrificed after 2 weeks of treatment after which OTM was measured. Hematoxylin/eosin-stained sections of the molars were prepared and the mesial roots were examined for resorption-lacunae depth and osteoclast number. ANOVA was used for statistical analysis (
resultsA significant decrease in OTM was observed only in the 2 g/l (
conclusionAccording to our findings, one of the effects of caffeine consumption during orthodontic treatment in rats was decreased root resorption. Additionally, concentrations of 2 g/l and 3 g/l inhibited OTM which seems to be due to its influence on osteoclast numbers.
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